Relationship between Urinary Level of Phytate and Valvular Calcification in an Elderly Population: A Cross-Sectional Study

Autor: Armando Bethencourt, Oriol Bonnin, Bernat Isern, Onofre J. Caldés, Antonia Costa-Bauzá, Andres Grau, Felix Grases, Joan Perelló, Pilar Sanchis, A. García-Raja, Carlos Fernández-Palomeque, Rafel M. Prieto
Jazyk: angličtina
Rok vydání: 2015
Předmět:
Male
Aging
ecocardiografía
humanos
Heart Valve Diseases
Physiology
lcsh:Medicine
Leukocyte Count
Cardiovascular calcification
enfermedades de las válvulas cardíacas
Risk Factors
Mitral valve
lcsh:Science
education.field_of_study
anciano
Multidisciplinary
válvulas cardíacas
Calcinosis
Heart Valves
medicine.anatomical_structure
Echocardiography
Population study
Mitral Valve
Female
Cardiomyopathies
Research Article
medicine.medical_specialty
Phytic Acid
ácido fítico
Urinary system
Population
Hypercholesterolemia
hipercolesterolemia
Phosphates
Calcification
Physiologic
recuento de leucocitos
Internal medicine
medicine
Diabetes Mellitus
factores de riesgo
Humans
education
envejecimiento
Aged
válvula mitral
business.industry
lcsh:R
medicine.disease
Endocrinology
Cross-Sectional Studies
Durapatite
Blood chemistry
miocardiopatías
fosfatos
lcsh:Q
business
durapatita
Calcification
estudios transversales
Zdroj: PLoS ONE, Vol 10, Iss 8, p e0136560 (2015)
PLoS ONE
ISSN: 1932-6203
Popis: Pathological calcification generally consists of the formation of solid deposits of hydroxyapatite (calcium phosphate) in soft tissues. Supersaturation is the thermodynamic driving force for crystallization, so it is believed that higher blood levels of calcium and phosphate increase the risk of cardiovascular calcification. However several factors can promote or inhibit the natural process of pathological calcification. This cross-sectional study evaluated the relationship between physiological levels of urinary phytate and heart valve calcification in a population of elderly out subjects. A population of 188 elderly subjects (mean age: 68 years) was studied. Valve calcification was measured by echocardiography. Phytate determination was performed from a urine sample and data on blood chemistry, end-systolic volume, concomitant diseases, cardiovascular risk factors, medication usage and food were obtained. The study population was classified in three tertiles according to level of urinary phytate: low (1.21 mu M). Subjects with higher levels of urinary phytate had less mitral annulus calcification and were less likely to have diabetes and hypercholesterolemia. In the multivariate analysis, age, serum phosphorous, leukocytes total count and urinary phytate excretion appeared as independent factors predictive of presence of mitral annulus calcification. There was an inverse correlation between urinary phytate content and mitral annulus calcification in our population of elderly out subjects. These results suggest that consumption of phytate-rich foods may help to prevent cardiovascular calcification evolution.
This work was supported by grant PI14/00853 from the Ministerio de Economia y Competitividad (Gobierno de Espana), and by FEDER funds (European Union). JP expresses his appreciation to Ministerio de Educacion y Cultura (Gobierno de Espana) for the fellowship of the FPU program. BI expresses his appreciation to the Conselleria d'Innovacio i Energia del (Govern de les Illes Balears) for the doctoral fellowship. PS express her appreciation for the postdoctoral fellowship PD/009/2013 to the Conselleria de Educacio, Cultura i Universitats (Govern de les Illes Balears) and the European Social Fund through the ESF Operational Programme of the Balearic Islands 2013-2017.
Databáze: OpenAIRE
Externí odkaz: