Dietary supplementation with monosodium glutamate with dietary balance such as protein, salt and sugar intake with increasing T1R3 taste receptor gene expression in healthy females
| Autor: | Rie Tsutsumi, Akari Yoshida, Hiroki Ohnishi, Yoshiaki Kitamura, Takahito Azuma, Tomoe Takashi, Masashi Kuroda, Chisa Fujimoto, Noriaki Takeda, Go Sato, Ryo Kanamura, Hiroshi Sakaue, Ayuka Kawakami, Kana Beppu, Hitoshi Shono, Eiji Kondo, Suzuno Watanabe |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Taste
medicine.medical_specialty Adolescent Monosodium glutamate Gene Expression Umami General Biochemistry Genetics and Molecular Biology Receptors G-Protein-Coupled chemistry.chemical_compound Taste receptor Tongue Internal medicine Sodium Glutamate medicine Humans Receptor Cross-Over Studies business.industry General Medicine Crossover study Dysgeusia medicine.anatomical_structure Endocrinology chemistry Dietary Supplements Female medicine.symptom business Sugars |
| Zdroj: | The journal of medical investigation : JMI. 68(3.4) |
| ISSN: | 1349-6867 |
| Popis: | We previously showed that chemotherapy-induced dysgeusia was associated with lingual taste receptor gene expression, and monosodium glutamate (MSG) improved dysgeusia by upregulating taste 1 receptor 3(T1R3) gene expression. In recent years, decreased taste sensitivity has also been reported in some young people, and these are partly due to their disordered eating habits. From these background, we investigated the effects of MSG supplementation on taste receptor expression and dietary intake in healthy females. Fifteen young healthy volunteers were enrolled for the present crossover study and divided in two groups (dietary supplementation with MSG at 2.7 g / day or 0.27 g / day). The relative expression of T1R3, a subunit of both umami and sweet taste receptors, in the tongue was assessed by quantitative PCR analysis. Food intake was assessed by food frequency questionnaire (FFQg), and body composition was measured using Omron HBF-701. T1R3 expression levels in the tongue and taste sensitivity increased significantly in participants who consumed10 g of MSG daily, whereas no alteration was observed in participants who consumed10 g of MSG daily. Furthermore, protein, fat, and carbohydrate (PFC) balance and salt and sugar intake improved by MSG supplementation. In conclusion, MSG supplementation increased T1R3 expression in the tongue and improved dietary balance. J. Med. Invest. 68 : 315-320, August, 2021. |
| Databáze: | OpenAIRE |
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