Feasibility and impact of an intensified antibiotic stewardship programme targeting cephalosporin and fluoroquinolone use in a tertiary care university medical center
| Autor: | Johannes P Borde, Klaus Kaier, Michaela Steib-Bauert, Werner Vach, Annette Geibel-Zehender, Hansjörg Busch, Hartmut Bertz, Martin Hug, Katja de With, Winfried V Kern |
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| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class Cephalosporin Antibiotics Tertiary care Drug Utilization Review Medical microbiology medicine Humans University medical Medical prescription Intensive care medicine Antibiotic stewardship Academic Medical Centers Cross Infection Tertiary Healthcare business.industry Incidence Incidence (epidemiology) Interrupted time-series analysis Drug Utilization Cephalosporins Anti-Bacterial Agents Infectious Diseases Emergency medicine Antibiotic Stewardship business Research Article Fluoroquinolones |
| Zdroj: | BMC Infectious Diseases |
| ISSN: | 1471-2334 |
| DOI: | 10.1186/1471-2334-14-201 |
| Popis: | Background Restricted use of third-generation cephalosporins and fluoroquinolones has been linked to a reduced incidence of hospital-acquired infections with multidrug-resistant bacteria. We implemented an intensified antibiotic stewardship (ABS) programme in the medical service of a university hospital center aiming at a reduction by at least 30% in the use of these two drug classes. Methods The ABS programme was focused on the 300-bed medical service. Prescription of third-generation cephalosporins was discouraged, whereas the use of penicillins was encouraged. Monthly drug use density was measured in WHO-ATC defined and locally recommended daily doses (DDD and RDD) per 100 patient days, to evaluate trends before (01/2008 to 10/2011) and after starting the intervention (1/2012 to 3/2013). The effect was analysed using interrupted time-series analysis with six non-intervention departments as controls. Results Following initiation of the ABS intervention, overall antibiotic use in the medical service declined (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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