Vincristine-induced vocal cord palsy: case report and review of the literature
| Autor: | Nor Azlin Kamal, Jeevanan Jahendran, Zarina Abdul Latiff, Jamal R, Syed Zulkifli Syed Zakaria, Hamidah Alias, Bee See Goh |
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| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty Vincristine Stridor Laryngoscopy otorhinolaryngologic diseases medicine Humans Vocal cord paralysis medicine.diagnostic_test business.industry Induction chemotherapy Hematology Precursor Cell Lymphoblastic Leukemia-Lymphoma medicine.disease Antineoplastic Agents Phytogenic Surgery Oncology Otorhinolaryngology Anesthesia Child Preschool Pediatrics Perinatology and Child Health Cordectomy Female medicine.symptom Complication business Vocal Cord Paralysis medicine.drug |
| Zdroj: | Journal of pediatric hematology/oncology. 32(5) |
| ISSN: | 1536-3678 |
| Popis: | Vincristine-induced vocal cord paralysis is a rare but serious complication. We report 2 patients with acute lymphoblastic leukemia who developed progressive stridor during induction chemotherapy. There were no clinical features of peripheral or autonomic neuropathy. Flexible laryngoscopy confirmed the diagnosis of bilateral vocal cord palsy; interestingly, the nerve conduction test revealed axonal motor neuropathy involving the median and common peroneal nerves in both patients. The first patient required prolonged ventilatory support necessitating unilateral cordectomy before extubation, whereas the second only required supplemental oxygen therapy. There was resolution of stridor in the first patient after cordectomy and gradual clinical improvement in the second. These cases illustrate that a high index of suspicion of vincristine-induced vocal cord palsy with prompt otolaryngology consultation for laryngoscopy is required in the diagnostic evaluation of a patient who has received vincristine. |
| Databáze: | OpenAIRE |
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