Bicarbonate, carbon dioxide and pH sensing via mammalian bicarbonate-regulated soluble adenylyl cyclase
| Autor: | Jochen Buck, Stephanie Jackvony, Lonny R. Levin, Tom Rossetti |
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| Rok vydání: | 2020 |
| Předmět: |
inorganic chemicals
Bicarbonate Cell Biomedical Engineering Biophysics Bioengineering Biochemistry digestive system ADCY10 Biomaterials 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Carbonic anhydrase medicine Cyclic adenosine monophosphate education 030304 developmental biology chemistry.chemical_classification 0303 health sciences education.field_of_study biology urogenital system Articles Soluble adenylyl cyclase Enzyme medicine.anatomical_structure chemistry Carbon dioxide embryonic structures biology.protein 030217 neurology & neurosurgery Biotechnology |
| Zdroj: | Interface Focus |
| ISSN: | 2042-8898 |
| Popis: | Soluble adenylyl cyclase (sAC; ADCY10) is a bicarbonate (HCO 3 − )-regulated enzyme responsible for the generation of cyclic adenosine monophosphate (cAMP). sAC is distributed throughout the cell and within organelles and, as such, plays a role in numerous cellular signalling pathways. Carbonic anhydrases (CAs) nearly instantaneously equilibrate HCO 3 − , protons and carbon dioxide (CO 2 ); because of the ubiquitous presence of CAs within cells, HCO 3 − -regulated sAC can respond to changes in any of these factors. Thus, sAC can function as a physiological HCO 3 − /CO 2 /pH sensor. Here, we outline examples where we have shown that sAC responds to changes in HCO 3 − , CO 2 or pH to regulate diverse physiological functions. |
| Databáze: | OpenAIRE |
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