Has the percutaneous vertebroplasty a role to prevent progression or local recurrence in spinal metastases of breast cancer?
| Autor: | Lise Le Jean, Sylvia Neuenschwander, Jacques Chiras, Evelyne Cormier, Beatriz Roedel, Sébastien Touraine, Luc Molet-Benhamou, Hervé Brisse, Frédéric Clarençon |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Breast Neoplasms Metastasis Percutaneous vertebroplasty Breast cancer medicine Humans Radiology Nuclear Medicine and imaging Aged Retrospective Studies Vertebroplasty Spinal Neoplasms Radiological and Ultrasound Technology business.industry Retrospective cohort study Middle Aged medicine.disease Metastatic breast cancer Surgery Radiation therapy Exact test Treatment Outcome Tumor progression Female Neurology (clinical) Radiology Neoplasm Recurrence Local business |
| Zdroj: | Journal of Neuroradiology. 42:222-228 |
| ISSN: | 0150-9861 |
| DOI: | 10.1016/j.neurad.2014.02.004 |
| Popis: | To evaluate the effectiveness of percutaneous vertebroplasty (PV) on the prevention of progression or local recurrence in patients with spinal metastases from breast cancer.Retrospective study on 55 patients between 27-78 years of age (mean age: 55 years) treated for metastatic breast cancer in the same institution (Curie institute, Paris, France), who underwent percutaneous vertebroplasty (PV) (number of vertebrae treated=137) for spinal metastases from January 2000 to December 2009 at the Pitié-Salpêtrière hospital. Statistical correlation between the local tumor progression/recurrence, and the presence of an epidural or a paravertebral metastatic extension at diagnosis, the rate of cement filling the lesion (50%, ≥50% but incomplete, complete/almost complete) and radiotherapy was evaluated using Chi(2) and Fisher's exact test.The rate of local tumor progression/recurrence of the vertebrae treated by vertebroplasty was 14% (19/137). No statistically significant correlation between either the rate of cement filling of the lesion, or the presence of an epidural or paravertebral metastatic extension, and progression/local recurrence after vertebroplasty was found. No influence of radiotherapy in preventing local progression/recurrence was noted. Distant new bone metastases were observed in 47 out of 55 patients (86%).The low rate of local tumor progression/recurrence after a vertebroplasty may support the hypothesis of an antitumor effect of the cement. |
| Databáze: | OpenAIRE |
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