Osteoarthritis-like pathologic changes in the knee joint induced by environmental disruption of circadian rhythms is potentiated by a high-fat diet
| Autor: | Robin M. Voigt, Martha Hotz Vitaterna, Beata Tryniszewska, Ranjan Kc, Hee Jeong Im, Qing-Jun Meng, Fred W. Turek, Ali Keshavarzian, Xin Li, Christopher B. Forsyth, Keith C. Summa |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Knee Joint Osteoarthritis Biology Environment Diet High-Fat Article Internal medicine medicine Animals Humans Circadian rhythm Obesity Eating habits Pathological Multidisciplinary Catabolism Cartilage homeostasis Body Weight Osteoarthritis Knee medicine.disease Circadian Rhythm Mice Inbred C57BL Disease Models Animal Endocrinology Fat diet Disease Progression Proteoglycans |
| Zdroj: | Scientific Reports |
| ISSN: | 2045-2322 |
| Popis: | A variety of environmental factors contribute to progressive development of osteoarthritis (OA). Environmental factors that upset circadian rhythms have been linked to various diseases. Our recent work establishes chronic environmental circadian disruption - analogous to rotating shiftwork-associated disruption of circadian rhythms in humans - as a novel risk factor for the development of OA. Evidence suggests shift workers are prone to obesity and also show altered eating habits (i.e., increased preference for high-fat containing food). In the present study, we investigated the impact of chronic circadian rhythm disruption in combination with a high-fat diet (HFD) on progression of OA in a mouse model. Our study demonstrates that when mice with chronically circadian rhythms were fed a HFD, there was a significant proteoglycan (PG) loss and fibrillation in knee joint as well as increased activation of the expression of the catabolic mediators involved in cartilage homeostasis. Our results, for the first time, provide the evidence that environmental disruption of circadian rhythms plus HFD potentiate OA-like pathological changes in the mouse joints. Thus, our findings may open new perspectives on the interactions of chronic circadian rhythms disruption with diet in the development of OA and may have potential clinical implications. |
| Databáze: | OpenAIRE |
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