Brief Research Report Regional Difference in TRAF2 and TRAF3 Gene Mutations in Colon Cancers
| Autor: | Seong Won Moon, Nam Jin Yoo, Hyun Ji Son, Sug Hyung Lee, Eun-Ji Choi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Research Report
Cancer Research congenital hereditary and neonatal diseases and abnormalities Tumor suppressor gene Colorectal cancer Gene mutation Biology medicine.disease_cause Pathology and Forensic Medicine Frameshift mutation expression medicine Biomarkers Tumor cancer Humans Frameshift Mutation Mutation Oncogene TNF Receptor-Associated Factor 3 fungi Microsatellite instability Cancer General Medicine DNA Neoplasm Brief Research Report medicine.disease Prognosis TNF Receptor-Associated Factor 2 digestive system diseases Society Journal Archive TRAF2 Oncology TRAF3 Case-Control Studies Colonic Neoplasms Cancer research Microsatellite Instability mutation |
| Zdroj: | Pathology and Oncology Research |
| ISSN: | 1532-2807 1219-4956 |
| Popis: | TRAF2 and TRAF3 genes of tumor necrosis factor receptor (TNF-R)-associated factor (TRAF) family are involved in diverse cell signaling, and function as both tumor suppressor gene and oncogene. Alterations of TRAF2 and TRAF3 in colon cancer (CC) along with their regional difference and microsatellite instability (MSI) are largely unknown. In the present study, we analyzed TRAF2 and TRAF3 frameshift mutations in 168 sporadic CCs (100 high MSI (MSI-H) and 68 microsatellite-stable (MSS) CCs). We identified TRAF2 and TRAF3 frameshift mutations in 4 (4%) and 3 CCs (3%) with MSI-H, respectively, but none in 68 cases of MSS CCs. Of the 168 CCs, we analyzed the mutations in multi-regions for 39 CCs (16 MSI-H and 23 MSS CCs), and discovered that 12.5% (2/16) and 6.3% (1/16) of MSI-H CCs exhibited regional difference in TRAF2 and TRAF3 mutations, respectively. In the multi-region samples of 23 MSS CCs, neither TRAF2 nor TRAF3 frameshift mutation was found. In 40% of CCs, both TRAF2 and TRAF3 expressions were increased compared to normal colon cells. Our data indicate that TRAF2 and TRAF3 frameshift mutations and their regional difference as well as altered expressions are present in MSI-H CCs, which could contribute to MSI-H cancer development. |
| Databáze: | OpenAIRE |
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