Dose-Response Studies for Pituitary and Testicular Function in Male Dogs Treated with the GnRH Superagonist, Deslorelin
| Autor: | Aris Junaidi, P. Williamson, T.E. Trigg, Margaret Blackberry, James M. Cummins, Graeme Martin |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty media_common.quotation_subject Deslorelin Testicle Gonadotropin-Releasing Hormone chemistry.chemical_compound Dogs Endocrinology Semen Internal medicine Testis Blood plasma medicine Carnivora Animals Testosterone media_common Drug Implants Triptorelin Pamoate Dose-Response Relationship Drug Sperm Count biology Fissipedia Contraceptive Agents Male Luteinizing Hormone biology.organism_classification Kinetics medicine.anatomical_structure chemistry Pituitary Gland Sperm Motility Animal Science and Zoology Reproduction Biotechnology Hormone |
| Zdroj: | Reproduction in Domestic Animals. 44:725-734 |
| ISSN: | 1439-0531 0936-6768 |
| DOI: | 10.1111/j.1439-0531.2008.01060.x |
| Popis: | We tested the effect of dose of GnRH superagonist on pituitary and testicular function in a study with four groups of four male dogs. The Controls received blank implants and the other three groups received implants containing 3, 6 or 12 mg deslorelin (D-Trp6-Pro9-des-Gly10-GnRH ethylamide). In all deslorelin-treated groups, there was initially an acute increase in plasma concentrations of LH and testosterone, followed by declines such that both hormones became undetectable after approximately 12 days. There was a dose-response in some of these early aspects of the hormone profiles. With respect to long-term effects of treatment, the 12-mg dose had significantly greater effects than the smaller doses for the duration of minimum testicular volume [366 +/- 77, mean +/- SEM (3 mg), 472 +/- 74 (6 mg), and 634 +/- 59 (12 mg) days], absence of ejaculate [416 +/- 88 (3 mg), 476 +/- 83 (6 mg), and 644 +/- 67 (12 mg) days], undetectable plasma concentrations of LH and testosterone [367 +/- 64 (3 mg), 419 +/- 72 (6 mg), and 607 +/- 69 (12 mg) days], the delay until complete recovery of LH and testosterone secretion [394 +/- 65 (3 mg), 484 +/- 72 (6 mg) and 668 +/- 47 (12 mg) days], and the delay until testes had regrown to normal volume [408 +/- 77 (3 mg), 514 +/- 74 (6 mg), 676 +/- 59 (12 mg) days]. The time taken to restore full ejaculates was also longest for the 12-mg dose: 716 +/- 67 (12 mg) days vs 440 +/- 66 (3 mg) and 538 +/- 83 (6 mg) days after implantation. There was no correlation between delay to recovery of normal ejaculate quality and body mass. We conclude that the dose-response relationship with deslorelin implants is not expressed with respect to the degree of suppression of reproduction, but on the maximum duration of suppression and thus to delay until recovery. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text