Ferrets as a model for higher-level visual motion processing
| Autor: | Augusto A. Lempel, Kristina J. Nielsen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
genetic structures Motion Perception Biology Stimulus (physiology) Motion processing General Biochemistry Genetics and Molecular Biology Article Visual processing 03 medical and health sciences 0302 clinical medicine Animal model medicine Animals Visual Pathways Visual Cortex Neurons Computational model Ferrets Visual motion processing Sulcus eye diseases 030104 developmental biology Visual cortex medicine.anatomical_structure Models Animal Female General Agricultural and Biological Sciences Neuroscience 030217 neurology & neurosurgery |
| Popis: | Summary Ferrets are a major developmental animal model due to their early parturition. Here we show for the first time that ferrets could be used to study development of higher-level visual processes previously identified in primates. In primates, complex motion processing involves primary visual cortex (V1), which generates local motion signals, and higher-level visual area MT, which integrates these signals over more global spatial regions. Our data show similar transformations in motion signals between ferret V1 and higher-level visual area PSS, located in the posterior bank of the suprasylvian sulcus. We found that PSS neurons, like MT neurons, were tuned for stimulus motion and showed strong suppression between opposing direction inputs. Most strikingly, PSS, like MT, exhibited robust global motion signals when tested with coherent plaids—the classic test for motion integration across multiple moving elements. These PSS responses were described well by computational models developed for MT. Our findings establish the ferret as a strong animal model for development of higher-level visual processing. |
| Databáze: | OpenAIRE |
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