Burden of kidney failure from atheroembolic disease and association with survival in people receiving dialysis in Australia and New Zealand: a multi-centre registry study
| Autor: | Andrea K. Viecelli, Isabelle Ethier, Carmel M. Hawley, Arnold C.T. Ng, David W. Johnson, Yeoungjee Cho, Elaine M. Pascoe, Tahira Scott |
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| Rok vydání: | 2021 |
| Předmět: |
Nephrology
Male medicine.medical_specialty Registry Survival medicine.medical_treatment Embolism Kidney failure Disease Cost of Illness Renal Dialysis Internal medicine Medicine Humans Registries Renal Insufficiency Multi centre Dialysis Aged Outcome Kidney business.industry Proportional hazards model Research Australia Middle Aged medicine.disease Atherosclerosis Comorbidity Diseases of the genitourinary system. Urology Confidence interval Survival Rate medicine.anatomical_structure Atheroembolic disease Female RC870-923 business New Zealand |
| Zdroj: | BMC Nephrology BMC Nephrology, Vol 22, Iss 1, Pp 1-9 (2021) |
| ISSN: | 1471-2369 |
| Popis: | Background Cardiovascular disease is a leading cause of mortality in kidney failure (KF). Patients with KF from atheroembolic disease are at higher risk of cardiovascular disease than other causes of KF. This study aimed to determine survival on dialysis for patients with KF from atheroembolic disease compared with other causes of KF. Methods All adults (≥ 18 years) with KF initiating dialysis as the first kidney replacement therapy between 1 January 1990 and 31 December 2017 according to the Australia and New Zealand Dialysis and Transplant registry were included. Patients were grouped into either: KF from atheroembolic disease and all other causes of KF. Survival outcomes were assessed by the Kaplan-Meier method and Cox regression analysis adjusted for patient-related characteristics. Results Among 65,266 people on dialysis during the study period, 334 (0.5%) patients had KF from atheroembolic disease. A decreasing annual incidence of KF from atheroembolic disease was observed from 2008 onwards. Individuals with KF from atheroembolic disease demonstrated worse survival on dialysis compared to those with other causes of KF (HR 1.80, 95% confidence interval [CI] 1.61–2.03). The respective one- and five-year survival rates were 77 and 23% for KF from atheroembolic disease and 88 and 47% for other causes of KF. After adjustment for patient characteristics, KF from atheroembolic disease was not associated with increased patient mortality (adjusted HR 0.93 95% CI 0.82–1.05). Conclusions Survival outcomes on dialysis are worse for individuals with KF from atheroembolic disease compared to those with other causes of KF, probably due to patient demographics and higher comorbidity. |
| Databáze: | OpenAIRE |
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