Tertiary lymphoid structures in cancer – considerations for patient prognosis
| Autor: | Valentine C. Marion, Roslyn A. Kemp, Luis Munoz-Erazo, Janet L. Rhodes |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty Immunology Context (language use) Review Article Models Biological 03 medical and health sciences 0302 clinical medicine Neoplasms medicine Immunology and Allergy Humans Practice Patterns Physicians' Cellular composition Tertiary Lymphoid Structures business.industry Cancer Germinal center medicine.disease Positive patient Prognosis 030104 developmental biology Infectious Diseases Treatment Outcome business 030215 immunology |
| Zdroj: | Cell Mol Immunol |
| Popis: | Tertiary lymphoid structures (TLS) are ectopic lymphoid formations that form within nonlymphoid tissue. They share structural and functional characteristics with secondary lymphoid structures such as lymph nodes and can contain B-cell follicles and germinal centers surrounded by a T-cell region. TLS have been described in several types of cancers and are usually associated with positive patient outcomes. However, TLS differ vastly in cellular composition and location within tissue types. In this review, we discuss factors confounding the interpretation of the evidence for a prognostic role for TLS in cancer and frame these factors in the context of translation to regular clinical use. |
| Databáze: | OpenAIRE |
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