Argonaute Proteins: From Structure to Function in Development and Pathological Cell Fate Determination

Autor:	Muller, M., Fazi, F., Ciaudo, C.
Rok vydání:	2019
Předmět:	argonaute proteins cancer development expression posttranslational modifications structure Cell and Developmental Biology Mini Review
Zdroj:	Frontiers in Cell and Developmental Biology Frontiers in Cell and Developmental Biology, 7
ISSN:	2296-634X
Popis:	The highly conserved Argonaute protein family members play a central role in the regulation of gene expression networks, orchestrating the establishment and the maintenance of cell identity throughout the entire life cycle, as well as in several human disorders, including cancers. Four functional Argonaute proteins (AGO1–4), with high structure similarity, have been described in humans and mice. Interestingly, only AGO2 is robustly expressed during human and mouse early development, in contrast to the other AGOs. Consequently, AGO2 is indispensable for early development in vivo and in vitro. Here, we review the roles of Argonaute proteins during early development by focusing on the interplay between specific domains of the protein and their function. Moreover, we report recent works highlighting the importance of AGO posttranslational modifications in cancer. Frontiers in Cell and Developmental Biology, 7 ISSN:2296-634X
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca6535a27e45ff4edf8ceb7425ec8f9a https://pubmed.ncbi.nlm.nih.gov/32039195 Zobrazit plný text záznamu