Poly-DL-lactide-co-glycolide microspheres as a controlled release antigen delivery system
| Autor: | K. M. Lima, J. M. Rodrigues Júnior |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1999 |
| Předmět: |
Physiology
Polymers medicine.medical_treatment Immunology Biophysics Biocompatible Materials Biochemistry Immunoadjuvant Microsphere Antigen Polylactic Acid-Polyglycolic Acid Copolymer adjuvant vaccine medicine Lactic Acid General Pharmacology Toxicology and Pharmaceutics Antigens lcsh:QH301-705.5 Vaccines lcsh:R5-920 Antigen delivery Chemistry General Neuroscience biomaterial Biomaterial Cell Biology General Medicine Biocompatible material Controlled release microspheres lcsh:Biology (General) microencapsulation lcsh:Medicine (General) Adjuvant Polyglycolic Acid Biomedical engineering |
| Zdroj: | Brazilian Journal of Medical and Biological Research, Vol 32, Iss 2 (1999) Brazilian Journal of Medical and Biological Research, Volume: 32, Issue: 2, Pages: 171-180, Published: FEB 1999 Brazilian Journal of Medical and Biological Research v.32 n.2 1999 Brazilian Journal of Medical and Biological Research Associação Brasileira de Divulgação Científica (ABDC) instacron:ABDC |
| Popis: | Successful vaccine application means maximum protection with minimal number of administrations. A rational development of vaccines involves studies of the nature of the antigen as well as of the adjuvant to be used to improve the immune responses. This has provided the impetus for studies to design the degradable devices and for different approaches to antigen delivery by different routes of administration. The development of controlled release systems based on polymeric devices that permit a sustained or pulsed release of encapsulated antigens has attracted much interest. Polymeric delivery systems consist of polymers that release their content continuously in a controlled manner over a period of time. The development of a biocompatible delivery system for parenteral administration offers several advantages in terms of immunoadjuvanticity over other compounds. It was found that, in contrast to other carriers, microspheres are more stable, thus permitting administration by the oral or parenteral route. In the present study, we describe the main characteristics and potentialities of this new immunoadjuvant for oral and parenteral administration. |
| Databáze: | OpenAIRE |
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