BRAF V600E mutation in papillary thyroid carcinoma: it’s relation to clinical features and oncologic outcomes in a single cancer centre experience
| Autor: | Awad Jarrar, Enas Younis, Rafal Iskanderian, Tawfiq Al-Shobaki, Abdelghani Tbakhi, Mahmoud Al-Masri, Hussam Haddad, Hani Al-Najjar, Niveen Abdallah, Zeinab Obeid, Mohammad AlMasri |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Poor prognosis endocrine system diseases Endocrinology Diabetes and Metabolism neoplasms Gastroenterology Diseases of the endocrine glands. Clinical endocrinology Thyroid carcinoma Middle East Endocrinology papillary Internal medicine Cancer centre Internal Medicine medicine thyroid cancer Thyroid cancer business.industry Research Cancer medicine.disease RC648-665 BRAF V600E Cohort Mutation (genetic algorithm) mutation business |
| Zdroj: | Endocrine Connections Endocrine Connections, Vol 10, Iss 12, Pp 1531-1537 (2021) |
| ISSN: | 2049-3614 |
| Popis: | Purpose This study focuses on the oncologic influence of BRAF V600E mutations in a cohort of Middle Eastern papillary thyroid carcinoma (PTC) patients treated at a single centre. We tested the association of BRAF V600E mutation with papillary thyroid carcinoma at King Hussein Cancer Center. Methods Patients with histologically confirmed PTC who underwent surgical treatment between 2006 and 2015 were included in this study. Oncological outcomes, both short- and long-termed, were collected. Results A total of 128 patients (68% females) were included in this study with a mean age of 38 years (±13.8). The median follow-up period was 50 months. The BRAF V600E mutation was found in 71% of patients. The tumour size for patients with a negative BRAF V600E mutation was significantly larger in comparison to patients who tested positive for the mutation (3.47 cm vs 2.31 cm, respectively, P = 0.009). The two groups showed similar disease-free survival (DFS) rates; positive = 75% (median 43 months (0–168)) compared to 78% for the negative BRAF V600E mutation (median 38 months (3–142)) (P = 0.162, HR = 0.731) Furthermore, both groups showed similar overall survival rates, positive = 94.5% (median 56 months (0–228)) compared to 94.6% for the negative BRAF V600E mutation (median 43 months (3–157)) (P = 0.941, HR = 0.940). Conclusion BRAF V600E mutation had no effect on loco-regional recurrence, distant metastasis, overall survival, or DFS. These findings may be attributed to geographic variations or reflect that BRAF V600E may only serve as an indicator of poor prognosis in high-risk group as such. |
| Databáze: | OpenAIRE |
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