| Autor: |
Francisco Lucas Faustino do Nascimento, Alana de Freitas Pires, Mário Rogério Lima Mota, Pedro Henrique Chaves Isaias, Diego Freitas de Araujo, Maria Gleiciane de Queiroz Martins, Cleane Gomes Moreira, João Batista Cajazeiras, Benildo Sousa Cavada, Kyria Santiago do Nascimento, Ana Maria Sampaio Assreuy |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Molecular biology reports. 49(9) |
| ISSN: |
1573-4978 |
| Popis: |
To investigate the effect and mechanisms of Andira anthelmia lectin in rat models of acute inflammation.AAL anti-inflammatory activity was evaluated in Wistar rat models of paw edema and peritonitis.AAL (0.01-1 mg/kg i.v.) was injected 30 min before stimulation with carrageenan and with initial and late phase inflammatory mediators into the animals paw or peritoneum for evaluation of cell migration (optical and intravital microscopy), paw edema (plethysmometry and histopathology); hyperalgesia (analgesimetry).AAL inhibited leukocyte migration induced by carrageenan, mainly neutrophils to the peritoneal fluid, decreasing leukocyte adhesion. In the peritoneal fluid, AAL reduced the gene expression of TNF-α and cyclooxygenase, as well the levels of PGEAAL presents anti-inflammatory effect in acute models of rat inflammation involving the participation of prostaglandins, TNF-α and lectin domain. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink