Impact of fatty liver disease and metabolic syndrome on incident type 2 diabetes; a population based cohort study
Autor: | Takao Kojima, Akihiro Obora, Michiaki Fukui, Masahide Hamaguchi, Takuya Fukuda, Yoshitaka Hashimoto, Kazuteru Mitsuhashi |
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Rok vydání: | 2017 |
Předmět: |
Adult
Male medicine.medical_specialty Alcohol Drinking Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Type 2 diabetes Gastroenterology Cohort Studies 03 medical and health sciences 0302 clinical medicine Endocrinology Japan Risk Factors Internal medicine Diabetes mellitus Nonalcoholic fatty liver disease medicine Humans Metabolic Syndrome business.industry Incidence Fatty liver Middle Aged medicine.disease Obesity Fatty Liver Diabetes Mellitus Type 2 030211 gastroenterology & hepatology Female Metabolic syndrome business Body mass index Cohort study |
Zdroj: | Endocrine journal. 64(11) |
ISSN: | 1348-4540 |
Popis: | Fatty liver disease and metabolic syndrome (MetS) are both shown to increase the risk of type 2 diabetes. The aim of this study was to investigate the combined effect of fatty liver and MetS on incident diabetes. In this cohort study of 17,810 participants, fatty liver was diagnosed by abdominal ultrasonography and MetS was defined by a joint interim statement. We divided the participants into four groups according to the presence of fatty liver and/or MetS. Type 2 diabetes was defined as HbA1c ≥6.5%, fasting plasma glucose ≥7.0 mmol/L or treatment for diabetes. During the follow up examination (median 5.1 years), 804 participants developed diabetes. Compared with non-MetS without fatty liver, hazard ratios (HR) for incident diabetes after adjusting for age, body mass index, smoking status, exercise habit, alcohol consumption, family history of diabetes logarithm of alanine aminotransferase and fasting plasma glucose, were as follow: 2.35 (95 % CI 1.91-2.89, p |
Databáze: | OpenAIRE |
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