Hypothalamic-pituitary-adrenocortical and gonadal axes and sympathoadrenal activity of adult male rats prenatally exposed to morphine
| Autor: | Dominique Croix, François Bernet, Isabelle Dutriez-Casteloot, Jean Lesage, Jean-Claude Beauvillain, Jean-Paul Dupouy, Jean-François Dedieu, Christine Laborie, Valérie Montel |
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| Rok vydání: | 1999 |
| Předmět: |
Male
Hypothalamo-Hypophyseal System endocrine system medicine.medical_specialty Corticotropin-Releasing Hormone medicine.drug_class Hypothalamus Pituitary-Adrenal System Gestational Age Biology Hippocampus chemistry.chemical_compound Receptors Glucocorticoid Adrenocorticotropic Hormone Pregnancy Corticosterone Internal medicine Adrenal Glands Testis medicine Animals Rats Wistar Testosterone Morphine General Neuroscience Body Weight Pituitary gonadal axis Androgen Rats Receptors Mineralocorticoid Endocrinology chemistry Mineralocorticoid Prenatal Exposure Delayed Effects Female Luteinizing hormone hormones hormone substitutes and hormone antagonists Glucocorticoid medicine.drug |
| Zdroj: | Neuroscience Letters. 263:1-4 |
| ISSN: | 0304-3940 |
| DOI: | 10.1016/s0304-3940(99)00086-5 |
| Popis: | The present investigation concerns 80–90 day-old male rats born from morphine-exposed mothers (2×10 mg/kg per day from days 11 to 18 of gestation which showed at birth reduced size and activity of the adrenals). This prenatal treatment did not significantly disturb under resting conditions: (1) the postnatal body growth up to week 10 after birth, (2) the activity of the pituitary gonadal axis (circulating luteinizing hormone (LH) and testosterone (T), weight of the testicles and seminal vesicles), (3) the activity of the hypothalamo-pituitary-adrenal axis (HPA) (hypothalamic corticoliberin (CRF) content, plasma adrenocorticotrophic hormone (ACTH) level, adrenal weight and corticosterone (B) content, plasma B level) as well as B max and K d of mineralocorticoid (type I) and glucocorticoid (type II) receptors to B in both the hippocampus and the hypothalamus. In contrast these rats showed reduced content of adrenals in noradrenaline (NA) and adrenaline (A) but increased circulating levels of A. |
| Databáze: | OpenAIRE |
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