Concentration-dependent effect of iron on gamma-linolenic acid toxicity in ZR-75-1 human breast tumor cells in culture
| Autor: | R.C. Cantrill, David F. Horrobin, Gregory W. Ells, Chisholm Ka |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Cancer Research
Cell Survival Linolenic acid Iron Breast Neoplasms Biology Ferrous Lipid peroxidation chemistry.chemical_compound Tissue culture Tumor Cells Cultured Humans gamma-Linolenic Acid gamma-Linolenic acid chemistry.chemical_classification Dose-Response Relationship Drug Drug Synergism Oncology chemistry Biochemistry Toxicity Female Lipid Peroxidation Drug Screening Assays Antitumor Intracellular Polyunsaturated fatty acid |
| Zdroj: | Cancer Letters. 72:99-102 |
| ISSN: | 0304-3835 |
| Popis: | Polyunsaturated fatty acids are cytotoxic to ZR-75-1 human breast tumor cells in culture. This effect may be potentiated by the simultaneous addition of iron. When cytotoxicity was measured in the presence of different concentrations of both gamma-linolenic acid and ferrous chloride there was an increase in cell death above concentrations of 9 microM and 0.05 microM, respectively. The potentiation of the effects of 18:3n-6 at low concentrations by the simultaneous addition of Fe(II) ions supports the contention that an alteration in the intracellular Fe(II)/Fe(III) ratio is necessary to promote autocatalytic lipid peroxidation. |
| Databáze: | OpenAIRE |
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