Histaminergic system in brain disorders: lessons from the translational approach and future perspectives
| Autor: | Carmem Gottfried, Kamila Castro, Taylor Gonchoroski, Diego Baronio, Rudimar dos Santos Riesgo, Geancarlo Zanatta |
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| Jazyk: | angličtina |
| Předmět: |
medicine.medical_specialty
Autism Central nervous system Encefalopatias Review Histaminergic system chemistry.chemical_compound Histamine receptor Transtorno do espectro autista medicine Receptor Psychiatry Brain disorders business.industry Antagonist Histaminergic medicine.disease Psychiatry and Mental health medicine.anatomical_structure Histamina chemistry Schizophrenia Wakefulness Psychopharmacology business Neuroscience Histamine |
| Zdroj: | Annals of General Psychiatry Repositório Institucional da UFRGS Universidade Federal do Rio Grande do Sul (UFRGS) instacron:UFRGS |
| ISSN: | 1744-859X |
| DOI: | 10.1186/s12991-014-0034-y |
| Popis: | Histamine and its receptors were first described as part of immune and gastrointestinal systems, but their presence in the central nervous system and importance in behavior are gaining more attention. The histaminergic system modulates different processes including wakefulness, feeding, and learning and memory consolidation. Histamine receptors (H1R, H2R, H3R, and H4R) belong to the rhodopsin-like family of G protein-coupled receptors, present constitutive activity, and are subjected to inverse agonist action. The involvement of the histaminergic system in brain disorders, such as Alzheimer’s disease, schizophrenia, sleep disorders, drug dependence, and Parkinson’s disease, is largely studied. Data obtained from preclinical studies point antagonists of histamine receptors as promising alternatives to treat brain disorders. Thus, clinical trials are currently ongoing to assess the effects of these drugs on humans. This review summarizes the role of histaminergic system in brain disorders, as well as the effects of different histamine antagonists on animal models and humans. |
| Databáze: | OpenAIRE |
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