Development of the enteric nervous system and its role in intestinal motility during fetal and early postnatal stages
| Autor: | Alan J. Burns, Joel C. Bornstein, Heather M. Young, Rachael R. Roberts |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Pathology
medicine.medical_specialty Motility Biology Enteric Nervous System Mice symbols.namesake medicine Animals Humans Hirschsprung Disease Zebrafish Hirschsprung's disease Gastrointestinal tract Neural crest Muscle Smooth Interstitial Cells of Cajal biology.organism_classification medicine.disease Small intestine Interstitial cell of Cajal medicine.anatomical_structure Neural Crest Pediatrics Perinatology and Child Health Immunology symbols Surgery Enteric nervous system Gastrointestinal Motility |
| Zdroj: | Seminars in Pediatric Surgery. 18:196-205 |
| ISSN: | 1055-8586 |
| DOI: | 10.1053/j.sempedsurg.2009.07.001 |
| Popis: | Motility patterns in the mature intestine require the coordinated interaction of enteric neurons, gastrointestinal smooth muscle, and interstitial cells of Cajal. In Hirschsprung's disease, the aganglionic segment causes functional obstruction, and thus the enteric nervous system (ENS) is essential for gastrointestinal motility after birth. Here we review the development of the ENS. We then focus on motility patterns in the small intestine and colon of fetal mice and larval zebrafish, where recent studies have shown that the first intestinal motility patterns are not neurally mediated. Finally, we review the development of gastrointestinal motility in humans. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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