Multifaceted antibiotic stewardship intervention using a participatory-action-research approach to improve antibiotic prescribing for urinary tract infections in frail elderly (ImpresU): study protocol for a European qualitative study followed by a pragmatic cluster randomised controlled trial
| Autor: | Sigurd Høye, Morten Lindbæk, Pär-Daniel Sundvall, Theo J M Verheij, Silje Rebekka Heltveit-Olsen, Ronny Gunnarsson, Cees M.P.M. Hertogh, Anna Kowalczyk, Alma C van de Pol, Nicolaas P.A. Zuithoff, Wim G Groen, Ingmarie Skoglund, Esther A.R. Hartman, Egill Snaebjörnsson Arnljots, Maciej Godycki-Ćwirko, Annelie A. Monnier, Tamara N Platteel |
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| Přispěvatelé: | Elderly care medicine, APH - Aging & Later Life |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Frail Elderly Participatory action research Inappropriate Prescribing Antimicrobial Stewardship primary care Intervention (counseling) Humans Antimicrobial stewardship Medicine Cluster randomised controlled trial Medical prescription Respiratory Tract Infections Aged Randomized Controlled Trials as Topic Protocol (science) Respiratory tract infections SARS-CoV-2 business.industry COVID-19 General Medicine Anti-Bacterial Agents Family medicine Urinary Tract Infections General practice / Family practice business medical education & training Qualitative research |
| Zdroj: | BMJ Open, 11(10):052552. BMJ Publishing Group ImpresU consortium 2021, ' Multifaceted antibiotic stewardship intervention using a participatory-action-research approach to improve antibiotic prescribing for urinary tract infections in frail elderly (ImpresU): study protocol for a European qualitative study followed by a pragmatic cluster randomised controlled trial ', BMJ Open, vol. 11, no. 10, 052552 . https://doi.org/10.1136/bmjopen-2021-052552 BMJ Open BMJ Open, Vol 11, Iss 10 (2021) |
| ISSN: | 2044-6055 |
| DOI: | 10.1136/bmjopen-2021-052552 |
| Popis: | IntroductionAlmost 60% of antibiotics in frail elderly are prescribed for alleged urinary tract infections (UTIs). A substantial part of this comprises prescriptions in case of non-specific symptoms or asymptomatic bacteriuria, for which the latest guidelines promote restrictiveness with antibiotics. We aim to reduce inappropriate antibiotic use for UTIs through an antibiotic stewardship intervention (ASI) that encourages to prescribe according to these guidelines. To develop an effective ASI, we first need a better understanding of the complex decision-making process concerning suspected UTIs in frail elderly. Moreover, the implementation approach requires tailoring to the heterogeneous elderly care setting.Methods and analysisFirst, we conduct a qualitative study to explore factors contributing to antibiotic prescribing for UTIs in frail elderly, using semi-structured interviews with general practitioners, nursing staff, patients and informal caregivers. Next, we perform a pragmatic cluster randomised controlled trial in elderly care organisations. A multifaceted ASI is implemented in the intervention group; the control group receives care as usual. The ASI is centred around a decision tool that promotes restrictive antibiotic use, supported by a toolbox with educational materials. For the implementation, we use a modified participatory-action-research approach, guided by the results of the qualitative study. The primary outcome is the number of antibiotic prescriptions for suspected UTIs. We aim to recruit 34 clusters with in total 680 frail elderly residents ≥70 years. Data collection takes place during a 5-month baseline period and a 7-month follow-up period. Finally, we perform a process evaluation. The study has been delayed for 6 months due to COVID-19 and is expected to end in July 2021.Ethics and disseminationEthical approvals and/or waivers were obtained from the ethical committees in Poland, the Netherlands, Norway and Sweden. The results will be disseminated through publication in peer-reviewed journals and conference presentations.Trial registration numberNCT03970356. |
| Databáze: | OpenAIRE |
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