Relationships Between Osteoprotegerin (OPG), Receptor Activator of Nuclear Factor κΒ Ligand (RANKL), and Growth Hormone (GH) Secretory Status in Short Children
| Autor: | Shufang Wu, De Luca F, Shott S, Flint J, Elizabeth Suarez |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Male
musculoskeletal diseases medicine.medical_specialty Adolescent Bone density Anabolism Endocrinology Diabetes and Metabolism Short stature Bone resorption Growth hormone deficiency Absorptiometry Photon Endocrinology Osteoprotegerin Bone Density Predictive Value of Tests Internal medicine Humans Medicine Insulin-Like Growth Factor I Child Receptor Bone Development biology Human Growth Hormone business.industry RANK Ligand NF-kappa B Infant medicine.disease Body Height Insulin-Like Growth Factor Binding Proteins Insulin-Like Growth Factor Binding Protein 3 RANKL Child Preschool Pediatrics Perinatology and Child Health biology.protein Regression Analysis Female medicine.symptom business |
| Zdroj: | Journal of Pediatric Endocrinology and Metabolism. 22 |
| ISSN: | 2191-0251 0334-018X |
| Popis: | UNLABELLED GH deficiency places children at risk for decreased bone density and increased fracture rates. The RANKL/RANK/OPG system plays an important role in linking bone formation to bone resorption. Although OPG is thought to be secreted as a compensatory response to states of low bone density, its concentrations have not been found to differ significantly between GH-deficient, acromegalic, and healthy adults. AIM To evaluate the associations between OPG and RANKL serum levels and GH secretory status in children. CHILDREN 54 short children were recruited. METHODS Serum OPG and RANKL, IGF-I, IGFBP-3, stimulated GH levels, bone DEXA results, and growth velocity were assessed. Regression modeling was used to evaluate significant predictors of OPG and RANKL levels. RESULTS There were no significant differences in OPG and RANKL serum levels or bone DEXA results between GH-deficient and GH-sufficient children. A statistically significant quadratic relationship between OPG and IGFBP-3 concentrations was observed. CONCLUSIONS IGFBP-3 was found to be the only significant predictor of OPG serum levels, allowing us to speculate that increased OPG levels may represent a compensatory response to the missing anabolic actions of IGF-I and/or GH in children with GH deficiency. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|