Clinical Efficacy and Patient Satisfaction with U-500 Insulin Pump Therapy in Patients with Type 2 Diabetes
| Autor: | Mitchell S. Hamburg, Tara Konrady, Deepti Bulchandani |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Male
Insulin pump medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Black People Type 2 diabetes Hypoglycemia White People Insulin Infusion Systems Endocrinology Insulin resistance Infusion therapy Internal medicine Diabetes mellitus medicine Humans Hypoglycemic Agents Insulin Retrospective Studies Glycated Hemoglobin Asian business.industry Body Weight General Medicine Middle Aged medicine.disease Surgery Diabetes Mellitus Type 2 Patient Satisfaction Regular insulin Female Insulin Resistance business |
| Zdroj: | Endocrine Practice. 13:721-725 |
| ISSN: | 1530-891X |
| Popis: | To determine the safety and efficacy of U-500 regular insulin in pump therapy and to assess satisfaction with U-500 insulin pump therapy in patients with type 2 diabetes and severe insulin resistance.We performed a retrospective review of medical records of 6 patients with type 2 diabetes and insulin resistance who had been using U-500 insulin pump therapy for at least 6 months. In addition, we conducted a telephone follow-up patient satisfaction survey.The mean age of the patients was 57 +/- 6 years. Of the 6 patients (3 men and 3 women), 4 were white, 1 was black, and 1 was Asian. The mean hemoglobin A1c value before continuous subcutaneous insulin infusion therapy with U-500 regular insulin was 9.1% +/- 1.8%, and the mean U-100 insulin dose required was 391 +/- 91 U/day. In comparison, the mean U-500 insulin dose required at 6 months was 59.2 +/- 13.6 U/day, which is equivalent to 296 +/- 68 U/day of U-100 insulin (P = 0.04), and the mean hemoglobin A1c value at 6 months after treatment with the insulin pump using U-500 regular insulin was 6.9% +/- 0.9% (P = 0.03). In addition, our study patients lost a mean of 6.1 lb during the 6-month period, and no patient had clinically significant episodes of hypoglycemia. The majority of the patients reported a higher satisfaction with the U-500 insulin pump therapy in comparison with conventional insulin treatment.U-500 insulin pump therapy is a novel alternative for patients with type 2 diabetes and severe insulin resistance who have not met glycemic control goals with use of standard intensive insulin regimens. |
| Databáze: | OpenAIRE |
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