The study of antimicrobial, anti-cancer, anti-inflammatory and α-glucosidase inhibitory activities of Nigronapthaphenyl, isolated from an extract of Nigrospora sphaerica
| Autor: | C. D. Wijayarathna, Kushan M. Ukwatta, Jennifer L. Lawrence |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0106 biological sciences
medicine.drug_class Endophytic fungi lcsh:QR1-502 Biology Bruguiera 01 natural sciences Microbiology Plant use of endophytic fungi in defense Anti-inflammatory Nigrospora sphaerica lcsh:Microbiology 030308 mycology & parasitology 03 medical and health sciences medicine Nigronapthaphenyl α glucosidase inhibitory lcsh:QH301-705.5 0303 health sciences Traditional medicine Bruguiera gymnorrhyza Cancer Endophytic fungus medicine.disease Antimicrobial biology.organism_classification medicine.drug_formulation_ingredient Infectious Diseases lcsh:Biology (General) 010606 plant biology & botany |
| Zdroj: | Mycology, Vol 10, Iss 4, Pp 222-228 (2019) |
| ISSN: | 2150-1211 2150-1203 |
| Popis: | A new compound, nigronapthaphenyl, was extracted from the endophytic fungus Nigrospora sphaerica isolated from a mangrove plant Bruguiera gymnorrhyza. The structure of the compound was elucidated by analysis of 1D and 2D NMR spectra and mass spectrometric data. It was tested in vitro for its antimicrobial activity, cytotoxicity, anti-inflammatory activity and for its ability to inhibit α-glucosidase. Nigronapthaphenyl showed antibacterial activities against Bacillus subtilis TISTR 088 and Bacillus cereus TISTR 688 with MIC values of 4 and 2 μg/mL respectively. Cytotoxicity against colon cancer cell line HCT 116 was found to be an IC50 value of 9.62 ± 0.5 μM . This further showed potential anti-inflammatory activity amounting to an IC50 of 6.2 ± 0.5 μM and also α-glucosidase inhibitory activity, with an IC50 value of 6.9 ± 0.5 μM. |
| Databáze: | OpenAIRE |
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