Lipoxygenase Inhibition by Anadanthoflavone, a New Flavonoid from the Aerial Parts ofAnadenanthera colubrina
| Autor: | Joshua D. Deschamps, Barbara N. Timmermann, Maria-Teresa Gutierrez-Lugo, Theodore R. Holman, Enrique Suarez |
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| Rok vydání: | 2004 |
| Předmět: |
Stereochemistry
Lipoxygenase Flavonoid Pharmaceutical Science Cinnamic acid Analytical Chemistry Inhibitory Concentration 50 chemistry.chemical_compound Betulinic acid Drug Discovery Humans Lipoxygenase Inhibitors Lupeol Flavonoids Pharmacology chemistry.chemical_classification Stigmasterol biology Plant Extracts Organic Chemistry Fabaceae Plant Components Aerial biology.organism_classification Complementary and alternative medicine chemistry Apigenin biology.protein Molecular Medicine Anadenanthera colubrina Phytotherapy |
| Zdroj: | Planta Medica. 70:263-265 |
| ISSN: | 1439-0221 0032-0943 |
| DOI: | 10.1055/s-2004-818920 |
| Popis: | Chemical investigation of the aerial parts of Anadenanthera colubrina led to the isolation of a new flavonoid named anadanthoflavone ( 1), along with 11 known compounds: alnusenol, lupenone, lupeol, betulinic acid, alpha-amyrin, beta-amyrin, beta-sitosterol, stigmasterol, apigenin, 4-hydroxybenzoic acid and cinnamic acid. The isolated compounds were evaluated for their inhibitory activity on human platelet 12-lipoxygenase (12-hLO), human reticulocyte 15-lipoxygenase (15-hLO) and soybean lipoxygenase-1 (15-sLO). Compound 1 was found to be active against 12-hLO and 15-hLO with IC50 values of 13 +/- 3 microM and 17 +/- 3 microM, respectively. Apigenin selectively inhibited the activity of 15-hLO (IC50 : 4.0 +/- 1 microM), while lupenone, lupeol and alpha-amyrin were found active against 15-sLO (IC50 : 22 +/- 3 microM, 35 +/- 9 microM and 15 +/- 3 microM, respectively). |
| Databáze: | OpenAIRE |
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