Evaluation of drug-carrier interactions in quaternary powder mixtures containing perindopril tert-butylamine and indapamide
| Autor: | Adam Voelkel, Bartłomiej Milanowski, Janina Lulek, Michał Teżyk, Kasylda Milczewska |
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| Rok vydání: | 2016 |
| Předmět: |
Chromatography
Gas Surface Properties Scanning electron microscope Silicon dioxide Colloidal silica Pharmaceutical Science Lactose 02 engineering and technology 010402 general chemistry 01 natural sciences chemistry.chemical_compound Specific surface area Inverse gas chromatography Organic chemistry Cellulose Drug Carriers Chemistry Silicon Dioxide 021001 nanoscience & nanotechnology Surface energy 0104 chemical sciences Microcrystalline cellulose Indapamide Perindopril Powders 0210 nano-technology Nuclear chemistry |
| Zdroj: | International Journal of Pharmaceutics. 503:29-35 |
| ISSN: | 0378-5173 |
| Popis: | Interactions occurring between components in the quaternary powder mixtures consisting of perindopril tert-butylamine, indapamide (active pharmaceutical ingredients), carrier substance and hydrophobic colloidal silica were examined. Two grades of lactose monohydrate: Spherolac(®) 100 and Granulac(®) 200 and two types of microcrystalline cellulose: M101D+ and Vivapur(®) 102 were used as carriers. We determined the size distribution (laser diffraction method), morphology (scanning electron microscopy) and a specific surface area of the powder particles (by nitrogen adsorption-desorption). For the determination of the surface energy of powder mixtures the method of inverse gas chromatography was applied. Investigated mixtures were characterized by surface parameters (dispersive component of surface energy, specific interactions parameters, specific surface area), work of adhesion and cohesion as well as Flory-Huggins parameter χ23('). Results obtained for all quaternary powder mixtures indicate existence of interactions between components. The strongest interactions occur for both blends with different types of microcrystalline cellulose (PM-1 and PM-4) while much weaker ones for powder mixtures with various types of lactose (PM-2 and PM-3). |
| Databáze: | OpenAIRE |
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