HCV infection in patients with primary defects of immunoglobulin production
| Autor: | Antonello Giovannetti, D. El Salman, Isabella Quinti, Fernando Aiuti, Alessandra Oliva, Roberto Paganelli, Rainaldi L, R. Rosso, Franco Pandolfi |
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| Rok vydání: | 1995 |
| Předmět: |
Adult
Male Hyper IgM syndrome Cirrhosis Adolescent hypogammaglobulinemia gammaglobulins Hepatitis C virus Immunology gamma-globulins Immunoglobulins hcv hepatitis hypogammaglobulinaemia Lymphocyte Activation medicine.disease_cause Agammaglobulinemia medicine Humans Immunology and Allergy Child Hepatitis biology medicine.diagnostic_test Common variable immunodeficiency Immunoglobulins Intravenous virus diseases Gamma globulin Hepatitis C Antibodies Middle Aged medicine.disease Hepatitis C Virology digestive system diseases Liver biopsy biology.protein RNA Viral Female Antibody Research Article |
| Zdroj: | Clinical and Experimental Immunology. 102:11-16 |
| ISSN: | 1365-2249 0009-9104 |
| Popis: | SUMMARY We tested for infection with hepatitis C virus (HCV) in 58 patients affected by humoral immunodeficiencies: 43 common variable immunodeficiency (CVI), two hyper IgM syndrome (HIM), two IgG subclass deficiency, four ataxia-telangiectasia (AT), and seven X-linked agamma-globulinaemia (XLA). While the assessment of serum specific HCV antibodies in some of these patients was not informative because of the impairment in specific antibody production, the reverse transcriptase polymerase chain reaction (RT-PCR) assay used to detect serum HCV RNA was a useful method for diagnosing infection. We found that 38% of late onset hypogamma-globulinaemic patients (CVI, HIM or IgG subclass deficiency) had evidence of HCV infection. HCV infection was not detectable in patients with XLA or AT. The majority of our pa hems had persistent viraemia. and those who underwent liver biopsy showed histological findings of chronic hepatitis. Moreover, we could demonstrate in vitro that eight of 18 HCV-infected patients were actively producing anti-HCV antibodies, despite their impaired antibody production. The high rate of HCV infection in hypogammaglobulinaemic patients could be related to several nosoeomial routes of transmission, including intravenous immune globulin administration. Despite the persistent viremia only two patients had cirrhosis and none had hepatocarcinoma. |
| Databáze: | OpenAIRE |
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