Anticancer activity studies of cubebin isolated from Piper cubeba and its synthetic derivatives
| Autor: | Dhanya S. Rajalekshmi, Sunil Varughese, Mangalam S. Nair, Arya R. Madhusoodhanan, Arun K. Bahulayan, Nisha Prakasan, Farha Arakkaveettil Kabeer, Remani Prathapan |
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| Rok vydání: | 2016 |
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Molecular food.ingredient Stereochemistry Clinical Biochemistry Pharmaceutical Science Apoptosis 01 natural sciences Biochemistry Lignans chemistry.chemical_compound food Cell Line Tumor Neoplasms Amide Drug Discovery Piper cubeba Humans MTT assay Molecular Biology chemistry.chemical_classification Piper biology 010405 organic chemistry Organic Chemistry biology.organism_classification Antineoplastic Agents Phytogenic In vitro 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry Cell culture Seeds Molecular Medicine Lactone |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 26:1767-1771 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/j.bmcl.2016.02.041 |
| Popis: | (-)-Cubebin, isolated from the seeds of Piper cubeba, and its five different types of derivatives (a total of 17), with varying functionalities, were tested for their in vitro anticancer activity against six human cancer cell lines (A549, K562, SiHa, KB, HCT116 and HT29) using MTT assay. Cubebin as well as its derivatives containing lactone and amide groups showed significant anticancer activity. In some of the tested cell lines, the amide derivatives showed higher activity. Morphological analysis indicated that these compounds act through apoptosis mediated pathway of cell death and we expect that these results will pave new paths in the development of novel anticancer agents by the derivatization of (-)-cubebin. |
| Databáze: | OpenAIRE |
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