Partitioning of Lipids at Domain Boundaries in Model Membranes
| Autor: | Siewert J. Marrink, Lars V. Schäfer |
|---|---|
| Přispěvatelé: | Groningen Biomolecular Sciences and Biotechnology, Zernike Institute for Advanced Materials, Molecular Dynamics |
| Rok vydání: | 2010 |
| Předmět: |
Biophysical Letter
Chemistry Vesicle Lipid Bilayers Biophysics Membranes Artificial Biological membrane HYBRID LIPIDS Lipids Domain (mathematical analysis) VESICLES Molecular dynamics Membrane Microdomains Membrane Biochemistry PLASMA-MEMBRANES Thermodynamics Molecule Computer Simulation Lipid bilayer RAFTS PHASE-SEPARATION |
| Zdroj: | Biophysical Journal, 99(12), L91-L93. CELL PRESS |
| ISSN: | 0006-3495 |
| DOI: | 10.1016/j.bpj.2010.08.072 |
| Popis: | Line-active molecules (“linactants”) that bind to the boundary interface between different fluid lipid domains in membranes have a strong potential as regulators of the lateral heterogeneity that is important for many biological processes. Here, we use molecular dynamics simulations in combination with a coarse-grain model that retains near-atomic resolution to identify lipid species that can act as linactants in a model membrane that is segregated into two lipid domains of different fluidity. Our simulations predict that certain hybrid saturated/unsaturated chain lipids can bind to the interface and lower the line tension, whereas cone-shaped lysolipids have a less pronounced effect. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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