Macrophage migration inhibitory factor levels in serum from patients with acute intracerebral hemorrhage: Potential contribution to prognosis
| Autor: | Ba Huajun, Lin Qun, Chen Xiandong, Chen Maohua, Sun Jun, Lu Chuan, Cai Jianyong, Jun-Xia Dai, Jian-Hu Lin |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty medicine.medical_treatment Clinical Biochemistry Inflammation Biochemistry Gastroenterology 03 medical and health sciences 0302 clinical medicine Hematoma Modified Rankin Scale Internal medicine otorhinolaryngologic diseases Humans Medicine cardiovascular diseases Macrophage Migration-Inhibitory Factors Aged Cerebral Hemorrhage Aged 80 and over Intracerebral hemorrhage business.industry Stroke scale Biochemistry (medical) General Medicine Middle Aged Prognosis medicine.disease Survival Analysis Pathophysiology nervous system diseases 030104 developmental biology Cytokine Anesthesia Acute Disease Female Macrophage migration inhibitory factor medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | Clinica Chimica Acta. 472:58-63 |
| ISSN: | 0009-8981 |
| DOI: | 10.1016/j.cca.2017.07.016 |
| Popis: | Background Intracerebral hemorrhage (ICH) pathophysiology involves inflammation. Macrophage migration inhibition factor (MIF), a pro-inflammatory cytokine, is related to prognosis of ischemic stroke. The aim of this study was to investigate whether serum MIF levels are associated with severity and outcomes in patients with acute ICH. Methods We enrolled a total of 120 consecutive ICH patients and 120 healthy controls and sampled blood on admission and at study entry respectively. Enzyme-linked immunosorbent assay was used to quantify serum MIF levels. Results Serum MIF levels were higher in patients compared with controls and correlated with hematoma volume, National Institutes of Health Stroke Scale (NIHSS) scores and plasma C-reactive protein levels. After adjusting for other significant outcome predictors, MIF in serum was an independent predictor of 6-month overall survival and unfavorable outcome (modified Rankin Scale score > 2). Areas under receiver-operating characteristic curve (ROC) of serum MIF levels, hematoma volume and NIHSS scores were similar for 6-month unfavorable outcome. Moreover, serum MIF levels significantly improved areas under ROC of hematoma volume and NIHSS scores. Conclusions MIF in serum might be a potential biomarker for reflecting inflammation, severity and prognosis of ICH patients. |
| Databáze: | OpenAIRE |
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