Context-dependent representations of movement in Drosophila dopaminergic reinforcement pathways
| Autor: | Raphael Cohn, Adrienne L. Fairhall, Vanessa Ruta, Andrew F. Siliciano, Aryeh Zolin, Rich Pang |
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| Rok vydání: | 2020 |
| Předmět: |
Dopamine
Movement Context (language use) Biology medicine Biological neural network Animals Reinforcement Mushroom Bodies General Neuroscience Dopaminergic Neurons Dopaminergic Smell medicine.anatomical_structure Microscopy Fluorescence Multiphoton Odor Dopaminergic pathways Mushroom bodies Odorants Drosophila Female Neuroscience Reinforcement Psychology medicine.drug Signal Transduction |
| Zdroj: | Nature neuroscience. 24(11) |
| ISSN: | 1546-1726 |
| Popis: | Dopamine plays a central role in motivating and modifying behavior, serving to invigorate current behavioral performance and guide future actions through learning. Here we examine how this single neuromodulator can contribute to such diverse forms of behavioral modulation. By recording from the dopaminergic reinforcement pathways of the Drosophila mushroom body during active odor navigation, we reveal how their ongoing motor-associated activity relates to goal-directed behavior. We found that dopaminergic neurons correlate with different behavioral variables depending on the specific navigational strategy of an animal, such that the activity of these neurons preferentially reflects the actions most relevant to odor pursuit. Furthermore, we show that these motor correlates are translated to ongoing dopamine release, and acutely perturbing dopaminergic signaling alters the strength of odor tracking. Context-dependent representations of movement and reinforcement cues are thus multiplexed within the mushroom body dopaminergic pathways, enabling them to coordinately influence both ongoing and future behavior. By recording from the Drosophila mushroom body during active odor navigation, Zolin et al. reveal that dopaminergic reinforcement pathways encode rewards and goal-directed actions through similar patterns of neural activity and dopamine release. |
| Databáze: | OpenAIRE |
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