Carbonic Anhydrase IX Expression in Renal Neoplasms
| Autor: | Sabina Signoretti, Pedram Argani, Chiara Grisanzio, Yihong Wang, Yineng Fu, Musie Ghebremichael, Robert M. Najarian, Elizabeth M. Genega |
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| Rok vydání: | 2010 |
| Předmět: |
Pathology
medicine.medical_specialty Chromophobe cell Biology urologic and male genital diseases Article Hurthle Cell Tumor Immunoenzyme Techniques Antigens Neoplasm Renal cell carcinoma Biomarkers Tumor medicine Carcinoma Adenoma Oxyphilic Humans Stromal tumor Carbonic Anhydrase IX Carcinoma Renal Cell Carbonic Anhydrases General Medicine medicine.disease Carcinoma Papillary Kidney Neoplasms Clear cell renal cell carcinoma Clear cell carcinoma Clear cell |
| Zdroj: | American Journal of Clinical Pathology. 134:873-879 |
| ISSN: | 1943-7722 0002-9173 |
| Popis: | Carbonic anhydrase IX (CAIX), a hypoxia-induced protein, is expressed in some renal tumors. We evaluated its immunohistochemical expression in 317 primary and 42 metastatic renal neoplasms (186 clear cell, 52 papillary, 35 chromophobe, 47 unclassified, and 15 Xp11.2 translocation renal cell carcinomas [RCCs]; 26 oncocytomas; 2 metanephric adenomas; 1 urothelial carcinoma; 1 mixed epithelial and stromal tumor; and 1 angiomyolipoma); 7 neoplasms were unknown as to whether they were primary or metastatic. We also correlated expression with tumor type and grade. Variable staining was seen in clear cell, papillary, unclassified, and Xp11.2 translocation carcinomas. One chromophobe carcinoma had focal expression. No staining was seen with other tumors. An association was found between high expression and clear cell vs non-clear cell carcinomas with all cases (P < .01) and primary (P < .01) cases. An association between CAIX expression and grade (P < .01) in primary clear cell carcinomas was found. CAIX expression is more common in clear cell RCC than other renal tumor types and is associated with grade. |
| Databáze: | OpenAIRE |
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