Penetration of micafungin into the burn eschar in patients with severe burns
| Autor: | Satoshi Yamanouchi, Satoshi Kishino, Naoki Aikawa, Junichi Sasaki, Yotaro Shinozawa, Shingo Hori, Yukio Sato, Shinya Abe |
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| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Antifungal Agents Eschar Echinocandins Lipopeptides Pharmacokinetics Healthy volunteers medicine Humans Initial treatment Pharmacology (medical) Severe burn In patient Dosing Aged Pharmacology business.industry Micafungin Middle Aged Surgery Anesthesia Female medicine.symptom Burns business medicine.drug |
| Zdroj: | European Journal of Drug Metabolism and Pharmacokinetics. 39:93-97 |
| ISSN: | 2107-0180 0378-7966 |
| Popis: | Micafungin (MCFG) concentrations in the plasma and in burn eschar were investigated after daily intravenous infusion (1 h) of MCFG (200 mg) in three patients with severe burns. MCFG treatment was initiated more than 72 h after the burn injuries. The MCFG concentrations in the plasma were determined at the end of the first administration of MCFG, immediately before the second dosing, at the end of the MCFG infusion after at least 4 days from the initial treatment, and immediately before the subsequent dosing using high-performance liquid chromatography. In addition, the trough levels in burn eschar after both the initial administration and repeated administration were measured. The peak and trough levels in the plasma were comparable to or slightly lower than the reported values in healthy volunteers. The mean (range) MCFG concentrations in the burn eschar after initial administration and repeated administration were 1.41 μg/mL ( |
| Databáze: | OpenAIRE |
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