A Glio-Protective Role of mir-263a by Tuning Sensitivity to Glutamate
| Autor: | Sherry Shiying Aw, Melissa Xue Mei Tang, Isaac Kok Hwee Lim, Stephen M. Cohen |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
glia Movement Excitotoxicity Glutamic Acid glutamate Biology medicine.disease_cause General Biochemistry Genetics and Molecular Biology Membrane Potentials 03 medical and health sciences astrocyte Glutamates Journal Article medicine Animals lcsh:QH301-705.5 Metabotropic glutamate receptor 8 microRNA Cell Death Metabotropic glutamate receptor 7 Cell Membrane neurodegeneration Metabotropic glutamate receptor 6 Glutamate receptor climbing defects Cell biology MicroRNAs 030104 developmental biology medicine.anatomical_structure Drosophila melanogaster Phenotype lcsh:Biology (General) nervous system Biochemistry Receptors Glutamate Metabotropic glutamate receptor Astrocytes Mutation NMDA receptor Drosophila Female movement disorder excitotoxicity Neuroglia Astrocyte Signal Transduction |
| Zdroj: | Aw, S S, Lim, I K H, Tang, M X M & Cohen, S M 2017, ' A Glio-Protective Role of mir-263a by Tuning Sensitivity to Glutamate ', Cell Reports, vol. 19, no. 9, pp. 1783-1793 . https://doi.org/10.1016/j.celrep.2017.05.010 Cell Reports, Vol 19, Iss 9, Pp 1783-1793 (2017) |
| ISSN: | 2211-1247 |
| DOI: | 10.1016/j.celrep.2017.05.010 |
| Popis: | Glutamate is a ubiquitous neurotransmitter, mediating information flow between neurons. Defects in the regulation of glutamatergic transmission can result in glutamate toxicity, which is associated with neurodegeneration. Interestingly, glutamate receptors are expressed in glia, but little is known about their function, and the effects of their misregulation, in these non-neuronal cells. Here, we report a glio-protective role for Drosophila mir-263a mediated by its regulation of glutamate receptor levels in glia. mir-263a mutants exhibit a pronounced movement defect due to aberrant overexpression of CG5621/Grik, Nmdar1, and Nmdar2. mir-263a mutants exhibit excitotoxic death of a subset of astrocyte-like and ensheathing glia in the CNS. Glial-specific normalization of glutamate receptor levels restores cell numbers and suppresses the movement defect. Therefore, microRNA-mediated regulation of glutamate receptor levels protects glia from excitotoxicity, ensuring CNS health. Chronic low-level glutamate receptor overexpression due to mutations affecting microRNA (miRNA) regulation might contribute to glial dysfunction and CNS impairment. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|