Left ventricular mechanics and cardiovascular outcomes in non-compaction phenotype
| Autor: | N Kuzo, Shehab Anwer, Lina Rebellius, Martin Meyer, Alexander Gotschy, Matthias Schindler, Sebastian Rogler, P S Heiniger, Julia Kebernik, Aju P. Pazhenkottil, Christiane Gruner, Dominik Schmid, Sinuhe Nussbaum, D Cassani, Renate Schoenenberger-Berzins, Ladina Erhart, Robert Manka, Felix C. Tanner |
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| Přispěvatelé: | University of Zurich, Tanner, Felix C |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Systole Heart Ventricles 610 Medicine & health Speckle tracking echocardiography 030204 cardiovascular system & hematology 2705 Cardiology and Cardiovascular Medicine Ventricular Function Left 03 medical and health sciences Ventricular Dysfunction Left 0302 clinical medicine Internal medicine Circumferential strain Medicine Humans 030212 general & internal medicine Twist Ventricular mechanics Ejection fraction Receiver operating characteristic 10042 Clinic for Diagnostic and Interventional Radiology business.industry Phenotype Echocardiography 10209 Clinic for Cardiology Cardiology Cardiology and Cardiovascular Medicine business Cardiovascular outcomes |
| Zdroj: | International journal of cardiology. 336 |
| ISSN: | 1874-1754 |
| Popis: | Aims This study aims at understanding left ventricular (LV) mechanics of non-compaction (LVNC) phenotype using echocardiographic strain analysis and at assessing the association of functional parameters with cardiovascular (CV) outcomes. Methods and results Longitudinal (GLS) and circumferential strain (GCS) as well as rotation of the LV were analyzed in 55 LVNC patients and 55 matched controls. Cardiovascular outcomes were documented for a median follow-up duration of 6 years. GLS and GCS were impaired in LVNC. Similary, regional longitudinal and circumferential strain as well as twist were reduced. CV events occurred in 28 LVNC patients. Apical peak circumferential strain (APCS), peak systolic rotation of apical segments (APSR), and twist were strongly associated with events. This was independent of and incremental to LVEF and non-compacted to compacted myocardial thickness ratio (NC:C ratio). The association of twist with events was also independent of and slightly superior to GLS. Conclusions GLS, GCS, regional strain, and twist were impaired in LVNC. APCS, APSR, and twist exhibited strong association with CV events independent of and incremental to LVEF and NC:C ratio, and in case of twist even GLS. Thus, STE-derived parameters may complement the echocardiographic assessment of LVNC patients in clinical routine. |
| Databáze: | OpenAIRE |
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