Force-mediated molecule release from double network hydrogels
| Autor: | Pavithra B. Jayathilaka, Kristopher A. Kilian, Shariful Islam, Yuwan Huang, Thomas G. Molley, Michael R. Buche, Jamie J. Kruzic, Meredith N. Silberstein |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
chemistry.chemical_classification
Polyacrylamide Oxanorbornadiene Double network Metals and Alloys 02 engineering and technology General Chemistry Polymer 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Catalysis Biological materials 0104 chemical sciences Surfaces Coatings and Films Electronic Optical and Magnetic Materials chemistry.chemical_compound chemistry Chemical engineering Self-healing hydrogels Materials Chemistry Ceramics and Composites Molecule Mechanosensitive channels 0210 nano-technology |
| Zdroj: | Chemical Communications. 57:8484-8487 |
| ISSN: | 1364-548X 1359-7345 |
| DOI: | 10.1039/d1cc02726c |
| Popis: | The incorporation of mechanosensitive linkages into polymers has led to materials with dynamic force responsivity. Here we report oxanorbornadiene cross-linked double network hydrogels that release molecules through a force-mediated retro Diels-Alder reaction. The molecular design and tough double network of polyacrylamide and alginate promote significantly higher activation at substantially less force than pure polymer systems. Activation at physiologically relevant forces provides scope for instilling dynamic mechanochemical behavior in soft biological materials. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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