Oral Antibiotic Exposure and Kidney Stone Disease
| Autor: | Michelle R. Denburg, Lawrence Copelovitch, Jeffrey S. Gerber, Gregory E. Tasian, David S. Goldfarb, Thomas Jemielita, Qufei Wu |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.drug_class Antibiotics 030232 urology & nephrology Administration Oral Penicillins Kidney Calculi 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine medicine Humans Clinical Epidemiology 030212 general & internal medicine Risk factor Methenamine business.industry Incidence Incidence (epidemiology) Age Factors General Medicine Odds ratio Middle Aged medicine.disease United Kingdom Confidence interval Anti-Bacterial Agents Cephalosporins Nitrofurantoin Nephrology Kidney stone disease Case-Control Studies Female Kidney stones business Fluoroquinolones medicine.drug |
| Zdroj: | Journal of the American Society of Nephrology. 29:1731-1740 |
| ISSN: | 1533-3450 1046-6673 |
| Popis: | Background Although intestinal and urinary microbiome perturbations are associated with nephrolithiasis, whether antibiotics are a risk factor for this condition remains unknown. Methods We determined the association between 12 classes of oral antibiotics and nephrolithiasis in a population-based, case–control study nested within 641 general practices providing electronic health record data for >13 million children and adults from 1994 to 2015 in the United Kingdom. We used incidence density sampling to match 25,981 patients with nephrolithiasis to 259,797 controls by age, sex, and practice at date of diagnosis (index date). Conditional logistic regression models were adjusted for the rate of health care encounters, comorbidities, urinary tract infections, and use of thiazide and loop diuretics, proton-pump inhibitors, and statins. Results Exposure to any of five different antibiotic classes 3–12 months before index date was associated with nephrolithiasis. The adjusted odds ratio (95% confidence interval) was 2.33 (2.19 to 2.48) for sulfas, 1.88 (1.75 to 2.01) for cephalosporins, 1.67 (1.54 to 1.81) for fluoroquinolones, 1.70 (1.55 to 1.88) for nitrofurantoin/methenamine, and 1.27 (1.18 to 1.36) for broad-spectrum penicillins. In exploratory analyses, the magnitude of associations was greatest for exposure at younger ages (P |
| Databáze: | OpenAIRE |
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