Mitochondrial protein import under kinase surveillance
| Autor: | Chris Meisinger, Magdalena Opalińska |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Applied Microbiology
Saccharomyces cerevisiae TIM/TOM complex preprotein Mitochondrion Biochemistry Genetics and Molecular Biology (miscellaneous) Microbiology Applied Microbiology and Biotechnology Unicellular organism Proteinkinase A (PKA) TOM complex Virology Genetics Protein kinase A (PKA) lcsh:QH301-705.5 Molecular Biology (CK2) Calcium signaling biology Mechanism (biology) Kinase Casein kinase (CK1) (CK2) Cell Biology biology.organism_classification Mitochondria Cell biology lcsh:Biology (General) Casein kinase (CK1) organellar biogenesis Parasitology Flux (metabolism) |
| Zdroj: | Microbial Cell Microbial Cell, Vol 1, Iss 2, Pp 51-57 (2014) |
| ISSN: | 2311-2638 |
| DOI: | 10.15698/mic2014.01.127 |
| Popis: | Despite the simplicity of the yeast Saccharomyces cerevisiae, its basic cellular machinery tremendously mirrors that of higher eukaryotic counterparts. Thus, this unicellular organism turned out to be an invaluable model system to study the countless mechanisms that govern life of the cell. Recently, it has also enabled the deciphering of signalling pathways that con- trol flux of mitochondrial proteins to the organelle according to metabolic requirements. For decades mitochondria were considered autonomous orga- nelles that are only partially incorporated into cellular signalling networks. Consequently, only little has been known about the role of reversible phos- phorylation as a meaningful mechanism that orchestrates mitochondrial bi- ology accordingly to cellular needs. Therefore, research in this direction has been vastly neglected. However, findings over the past few years have changed this view and new exciting fields in mitochondrial biology have emerged. Here, we summarize recent discoveries in the yeast model system that point towards a vital role of reversible phosphorylation in regulation of mitochondrial protein import. |
| Databáze: | OpenAIRE |
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