NF-kappaB regulates spatial memory formation and synaptic plasticity through protein kinase A/CREB signaling
| Autor: | Sylvie Mémet, Alain Israël, Antje Lindecke, Delphine Ndiaye, Martin Korte, Barbara Kaltschmidt, Stéphanie Pothion, Volker Staiger, Julia Pfeiffer, Maria Prüllage, Laurence Arbibe, Christian Kaltschmidt |
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| Přispěvatelé: | Institut für Neurobiochemie, Universität Witten Herdecke, Signalisation Moléculaire et Activation Cellulaire (SMAC), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Department of Cellular and Systems Neurobiology [MPIN Martinsried], Max-Planck-Institut für Neurobiologie (MPIN), Max-Planck-Gesellschaft-Max-Planck-Gesellschaft, Centre d'Innovation, Key-Obs SA, Key-Obs SA, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
Male
MESH: Hippocampus Electrophoretic Mobility Shift Assay Hippocampus Synaptic Transmission Mice 0302 clinical medicine MESH: Animals MESH: Memory Phosphorylation Cyclic AMP Response Element-Binding Protein Neuronal memory allocation Cells Cultured 0303 health sciences MESH: Electrophysiology NF-kappa B Articles Immunohistochemistry Cell biology Electrophysiology MESH: Forskolin MESH: Cells Cultured MESH: Cyclic AMP Response Element-Binding Protein Epigenetics in learning and memory Mice Transgenic MESH: Cyclic AMP-Dependent Protein Kinases Neurotransmission Biology CREB 03 medical and health sciences MESH: Gene Expression Profiling CREB in cognition Memory Animals [SDV.BBM]Life Sciences [q-bio]/Biochemistry Molecular Biology Protein kinase A Molecular Biology Transcription factor 030304 developmental biology Gene Expression Profiling Colforsin MESH: Immunohistochemistry Cell Biology Molecular biology Cyclic AMP-Dependent Protein Kinases MESH: Male MESH: Mi Synaptic plasticity MESH: Electrophoretic Mobility Shift Assay biology.protein 030217 neurology & neurosurgery |
| Zdroj: | Molecular and Cellular Biology Molecular and Cellular Biology, 2007, 26 (8), pp.2936-46. ⟨10.1128/MCB.26.8.2936-2946.2006⟩ Molecular and Cellular Biology, American Society for Microbiology, 2007, 26 (8), pp.2936-46. ⟨10.1128/MCB.26.8.2936-2946.2006⟩ |
| ISSN: | 0270-7306 1098-5549 |
| Popis: | International audience; Synaptic activity-dependent de novo gene transcription is crucial for long-lasting neuronal plasticity and long-term memory. In a forebrain neuronal conditional NF-kappaB-deficient mouse model, we demonstrate here that the transcription factor NF-kappaB regulates spatial memory formation, synaptic transmission, and plasticity. Gene profiling experiments and analysis of regulatory regions identified the alpha catalytic subunit of protein kinase A (PKA), an essential memory regulator, as a new NF-kappaB target gene. Consequently, NF-kappaB inhibition led to a decrease in forskolin-induced CREB phosphorylation. Collectively, these results disclose a novel hierarchical transcriptional network involving NF-kappaB, PKA, and CREB that leads to concerted nuclear transduction of synaptic signals in neurons, accounting for the critical function of NF-kappaB in learning and memory. |
| Databáze: | OpenAIRE |
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