Nifedipine GITS replacing nifedipine SR: ambulatory blood pressure assessment of efficacy
| Autor: | Talma Rosenthal, Naomi Nussinovitch, Arieh Katz, Carmit Rahima-Maoz, Ehud Grossman |
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| Rok vydání: | 1997 |
| Předmět: |
Adult
Male Ambulatory blood pressure Nifedipine Chemistry Pharmaceutical Blood Pressure medicine Humans Pharmacology (medical) Prospective Studies Antihypertensive Agents Aged Aged 80 and over Relative efficacy Dose-Response Relationship Drug business.industry Blood Pressure Monitoring Ambulatory Middle Aged Nifedipine gits Compliance (physiology) Blood pressure Treatment Outcome Tolerability Anesthesia Delayed-Action Preparations Ambulatory Hypertension Female Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Cardiology. 88 |
| ISSN: | 0008-6312 |
| Popis: | The relative efficacy of two formulations of nifedipine, slow release (SR) and gastrointestinal therapeutic system (GITS), to lower blood pressure in hypertensive patients was evaluated in a prospective study. Nifedipine GITS 30 mg/day replaced nifedipine SR, 20 mg b.i.d. in 38 patients, 23 monitored by routine blood pressure measurements and 15 by ambulatory monitoring. Nifedipine GITS achieved a marked reduction in blood pressure with a smaller dose than nifedipine SR: 30 versus 40 mg/day, respectively. It is concluded that patients with hypertension controlled on a twice-daily dose of nifedipine prolonged action can be converted to a lower once-daily dose of nifedipine GITS without experiencing any increase in blood pressure. Tolerability and compliance improved when switching to the GITS formulation. |
| Databáze: | OpenAIRE |
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