Successful treatment of localised radiation lesions in rats and humans by mesenchymal stem cell transplantation
| Autor: | Kotenko Kv, N M Nadezhina, Andrey Bushmanov, D. Grinakovskaya, Lebedev Vg, Y. Zhgutov, Moroz Bb, J. Deshevoy, I A Galstyan, T S Slobodina, I.I. Eremin |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Wound Healing
medicine.medical_specialty Pathology Radiation Radiological and Ultrasound Technology Radiation ulcers business.industry Mesenchymal stem cell Public Health Environmental and Occupational Health Mesenchymal Stem Cells General Medicine Mesenchymal Stem Cell Transplantation Beta Particles Rats Surgery Conservative treatment Transplantation medicine Deep beam Animals Humans Radiology Nuclear Medicine and imaging Stem cell business |
| Zdroj: | Radiation Protection Dosimetry. 151:661-665 |
| ISSN: | 1742-3406 0144-8420 |
| Popis: | Transplantation of mesenchymal stem cells (MSCs), at early and later stages after local exposure of rats to 140 Gy 90Sr/ 90Y beta radiation, was found to stimulate recovery of damaged skin. The area of local radiation injuries (LRIs) and accelerated healing of radiation ulcers was obtained. Clinical evolution showed the high efficiency of the transplantations of autologous MSCs for the treatment of deep beam ulcers, usually refractive to standard conservative treatment. Analogous to our results in the rats the authors obtained promising results with the application of MSCs for the treatment of severe LRIs in two human patients. Their radiation ulcers showed complete healing after stem cell application. Thus, further developments should determine the best possible conditions for MSC use in LRI treatment. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|