Serum and urine nickel in nickel-sensitized women: effects of oral challenge with the metal
| Autor: | P. Bavazzano, R. Pietra, S Masci, Paolo Amerio, M. Di Gioacchino, M. Andreassi, Paolo Boscolo, Enrico Sabbioni |
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| Rok vydání: | 1998 |
| Předmět: |
Adult
medicine.medical_specialty Time Factors Urticaria Provocation test Eczema Administration Oral Dermatology Urine Drug Hypersensitivity Atopy Pharmacokinetics Nickel Recurrence Oral administration Internal medicine medicine Humans Immunology and Allergy Ingestion Toxicokinetics Chemistry Allergens Thorax medicine.disease Endocrinology Case-Control Studies Creatinine Data Interpretation Statistical Immunology Female Immunization Contact dermatitis Facial Dermatoses Neck |
| Zdroj: | Contact Dermatitis. 38:5-8 |
| ISSN: | 1600-0536 0105-1873 |
| Popis: | 15 women with a positive patch test only to nickel (Ni) and without atopy and 10 control women were selected for the study. Blood and urine specimens were collected with a standard procedure either before (at 8 a.m.) or 4 and 24 h after the ingestion of 10 mg of Ni (as Ni sulfate). 7 of the Ni-sensitized patients showed a flare-up of eczema and/or urticaria during the test, while the other women were non-symptomatic. Serum and urine Ni of controls and Ni-sensitized women did not significantly differ. Serum and urine Ni levels determined before the oral Ni challenge were in the range of reference values recently reported by other authors (0.2-2.0 micrograms/l of serum or urine). Ni was greatly augmented in urine and serum 4 h after the challenge (25th-75th percentiles: 43-264 micrograms/l urine Ni and 15-52 micrograms/l serum Ni). 24 h after Ni ingestion, urine Ni was 41-153 micrograms/l and serum Ni 4-17 micrograms/l. Our study confirms a previous investigation showing similar levels of serum and urine Ni following ingestion of the metal in control and Ni-sensitized women without atopy. |
| Databáze: | OpenAIRE |
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