Tissue-specific regulation of SIRT1 by calorie restriction
| Autor: | Erin J. Easlon, Su Ju Lin, Hwei Ling Cheng, Danica Chen, Frederick W. Alt, Joanne Bruno, Leonard Guarente |
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| Rok vydání: | 2008 |
| Předmět: |
animal structures
endocrine system diseases Adipose Tissue White Calorie restriction Longevity Biology Mice Research Communication Sirtuin 1 Genetics Animals Sirtuins Muscle Skeletal Caloric Restriction Regulation of gene expression Mice Knockout NAD Phenotype Yeast Cell biology enzymes and coenzymes (carbohydrates) Biochemistry Gene Expression Regulation Liver Organ Specificity Sirtuin Knockout mouse biology.protein NAD+ kinase biological phenomena cell phenomena and immunity hormones hormone substitutes and hormone antagonists Developmental Biology |
| Zdroj: | Genesdevelopment. 22(13) |
| ISSN: | 0890-9369 |
| Popis: | Calorie restriction (CR) has been reported to increase SIRT1 protein levels in mice, rats, and humans, and elevated activity of SIRT1 orthologs extends life span in yeast, worms, and flies. In this study, we challenge the paradigm that CR induces SIRT1 activity in all tissues by showing that activity of this sirtuin in the liver is, in fact, reduced by CR and activated by a high-caloric diet. We demonstrate this change both by assaying levels of SIRT1 and its small molecule regulators, NAD and NADH, as well as assessing phenotypes of a liver-specific SIRT1 knockout mouse on various diets. Our findings suggest that designing CR mimetics that target SIRT1 to provide uniform systemic benefits may be more complex than currently imagined. |
| Databáze: | OpenAIRE |
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