β-Trace protein — A marker of kidney function in children: 'Original research communication–clinical investigation'
| Autor: | Joachim Schmitt, Ingo Franke, Michael J. Lentze, Gesche Düker, Stefan Buderus, Birgit Stoffel-Wagner, Michael Schlieber, Arend Bökenkamp |
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| Rok vydání: | 2007 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Clinical Biochemistry Renal function Reference range Lipocalin Kidney Function Tests chemistry.chemical_compound Internal medicine medicine Humans Cystatin C Child Creatinine biology Chemistry Beta-2 microglobulin β trace protein General Medicine medicine.disease Cystatins Lipocalins Intramolecular Oxidoreductases Endocrinology biology.protein Female beta 2-Microglobulin Biomarkers Glomerular Filtration Rate Kidney disease |
| Zdroj: | Clinical Biochemistry. 40:969-975 |
| ISSN: | 0009-9120 |
| Popis: | Objectives: To determine the pediatric reference interval for serum β-trace protein (β-TP) and to compare β-TP with established LMW markers of GFR, i.e., cystatin C (CysC) and β 2 -microglobulin (β 2 -M). Design and methods: All three LMW markers were measured immunonephelometrically. In 106 children above the age of 2 years without evidence of kidney disease, non-parametric reference intervals were calculated. The relative rise of the GFR marker concentrations above the upper reference was studied in 107 samples from 96 patients covering the entire GFR range. Results: Above 2 years, the reference range of β-TP was constant at 0.43–1.04 mg/L. With decreasing Schwartz-GFR, there was a comparable rise in β-TP and β 2 -M, while CysC rose less in the group with GFR below 30 mL/min/1.73 m 2 (278 ± 49% [CysC] versus 336 ± 65% [β-TP] and 342 ± 76% [β 2 -M]; p = 0.043 and 0.027, respectively). Conclusions: These data confirm the potential of s-TP as an endogenous GFR marker in children. |
| Databáze: | OpenAIRE |
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