Higher circular RNA_0015278 correlates with absence of extrathyroidal invasion, lower pathological tumor stages, and prolonged disease‐free survival in papillary thyroid carcinoma patients

Autor: Huajie Ding, Xiaojie Wang, Lei Na, Huiling Liu
Jazyk: angličtina
Rok vydání: 2021
Předmět:
0301 basic medicine
Microbiology (medical)
Adult
Male
Disease free survival
medicine.medical_specialty
circular RNA_0015278
overall survival
Clinical Biochemistry
Gastroenterology
Disease-Free Survival
Thyroid carcinoma
03 medical and health sciences
0302 clinical medicine
Internal medicine
Cell Line
Tumor
Tumor stage
Overall survival
Immunology and Allergy
Medicine
Humans
Neoplasm Invasiveness
Thyroid Neoplasms
Stage (cooking)
Pathological
Research Articles
Neoplasm Staging
Proportional Hazards Models
business.industry
Mortality rate
Biochemistry (medical)
Thyroid
Public Health
Environmental and Occupational Health
Hematology
tumor characteristics
RNA
Circular
Middle Aged
Gene Expression Regulation
Neoplastic
Medical Laboratory Technology
030104 developmental biology
medicine.anatomical_structure
Thyroid Cancer
Papillary
030220 oncology & carcinogenesis
papillary thyroid carcinoma
Female
disease‐free survival
business
Research Article
Zdroj: Journal of Clinical Laboratory Analysis
ISSN: 1098-2825
0887-8013
Popis: Background Circular RNA_0015278 (circ_0015278) inhibits the progression of several cancers and is greatly reduced in papillary thyroid carcinoma (PTC) tissues compared with benign thyroid lesions by microarray profiling. This study aimed to further investigate the correlation of circ_0015278 with tumor characteristics and prognosis in PTC patients. Methods Totally, 206 PTC patients who underwent tumor resection were retrospectively enrolled; subsequently, circ_0015278 expression in their tumor and adjacent tissues was detected by reverse transcriptional‐quantitative polymerase chain reaction. Besides, disease‐free survival (DFS) and overall survival (OS) were calculated. Results Circ_0015278 was reduced in tumor tissues compared with adjacent tissues (p
Circular RNA_0015278 (circ_0015278) inhibits the progression of several cancers and is greatly reduced in papillary thyroid carcinoma (PTC) tissues compared with benign thyroid lesions by microarray profiling. This study aimed to further investigate the correlation of circ_0015278 with tumor characteristics and prognosis in PTC patients. Totally, 206 PTC patients who underwent tumor resection were retrospectively enrolled; subsequently, circ_0015278 expression in their tumor and adjacent tissues was detected by reverse transcriptional‐quantitative polymerase chain reaction. Besides, disease‐free survival (DFS) and overall survival (OS) were calculated. Circ_0015278 was reduced in tumor tissues compared with adjacent tissues (p
Databáze: OpenAIRE
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