Concurrent infection with Mycobacterium tuberculosis confers robust protection against secondary infection in macaques

Autor: JoAnne L. Flynn, Constance J. Martin, Sarah M. Fortune, Allison F. Carey, Eileen A. Wong, Anthony M. Cadena, Pauline Maiello, Philana Ling Lin, Forrest F. Hopkins, Hannah P. Gideon, Peter Andersen, Robert M. DiFazio
Jazyk: angličtina
Rok vydání: 2018
Předmět:
0301 basic medicine
Monkeys
Macaque
Biochemistry
Diagnostic Radiology
White Blood Cells
Animal Cells
Medicine and Health Sciences
DNA libraries
Biology (General)
Tuberculosis Vaccines
Immune Response
Mammals
0303 health sciences
biology
T Cells
Coinfection
Radiology and Imaging
Vaccination
Infection Imaging
Eukaryota
3. Good health
Actinobacteria
Nucleic acids
Granuloma
Vertebrates
Granulomas
medicine.symptom
Cellular Types
Research Article
Primates
Tuberculosis
Imaging Techniques
QH301-705.5
Secondary infection
Immune Cells
030106 microbiology
Immunology
Inflammation
Research and Analysis Methods
Microbiology
Mycobacterium tuberculosis
03 medical and health sciences
Immune system
Immunity
Diagnostic Medicine
Virology
biology.animal
Old World monkeys
medicine
Genetics
Animals
Molecular Biology
Tuberculosis
Pulmonary
030304 developmental biology
Blood Cells
Biology and life sciences
Bacteria
030306 microbiology
business.industry
Organisms
Cell Biology
DNA
Pneumonia
RC581-607
medicine.disease
biology.organism_classification
030104 developmental biology
Amniotes
Macaca
Parasitology
Immunologic diseases. Allergy
business
Zdroj: PLoS Pathogens, Vol 14, Iss 10, p e1007305 (2018)
PLoS Pathogens
ISSN: 1553-7374
1553-7366
Popis: For many pathogens, including most targets of effective vaccines, infection elicits an immune response that confers significant protection against reinfection. There has been significant debate as to whether natural Mycobacterium tuberculosis (Mtb) infection confers protection against reinfection. Here we experimentally assessed the protection conferred by concurrent Mtb infection in macaques, a robust experimental model of human tuberculosis (TB), using a combination of serial imaging and Mtb challenge strains differentiated by DNA identifiers. Strikingly, ongoing Mtb infection provided complete protection against establishment of secondary infection in over half of the macaques and allowed near sterilizing bacterial control for those in which a secondary infection was established. By contrast, boosted BCG vaccination reduced granuloma inflammation but had no impact on early granuloma bacterial burden. These findings are evidence of highly effective concomitant mycobacterial immunity in the lung, which may inform TB vaccine design and development.
Author summary Tuberculosis (TB), a lung disease caused by the bacterial pathogen Mycobacterium tuberculosis, is endemic in many developing countries. This infection is transmitted from a person with active tuberculosis through coughing, talking, and singing. Exposure to this bacterium can result in a spectrum of infection outcomes, including in the majority of persons asymptomatic infection, known as latent TB. However, re-exposure to those with active disease occurs frequently, particularly in crowded conditions. Here we demonstrate that ongoing Mtb infection in a non-human primate model provides robust protection against reinfection and disease. This has important implications for vaccine development against this infection.
Databáze: OpenAIRE
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