Human Chorionic Gonadotropin and Plasma Protein-A in Alpha0-Thalassemia Pregnancies
| Autor: | Chin Peng Lee, Elizabeth T. Lau, Mary Hoi Yin Tang, Charas Y. T. Ong, Kwok Yin Leung |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Adult
medicine.medical_specialty Pregnancy-associated plasma protein A Prenatal diagnosis Sensitivity and Specificity alpha-Thalassemia Predictive Value of Tests Pregnancy Prenatal Diagnosis hemic and lymphatic diseases Blood plasma medicine Humans Pregnancy-Associated Plasma Protein-A Chorionic Gonadotropin beta Subunit Human False Positive Reactions Fetus Obstetrics business.industry Homozygote Pregnancy Complications Hematologic Obstetrics and Gynecology medicine.disease Blood proteins Fetal Diseases Pregnancy Trimester First Case-Control Studies Gestation Female business Biomarkers Blood sampling |
| Zdroj: | Obstetrics & Gynecology. 108:651-655 |
| ISSN: | 0029-7844 |
| DOI: | 10.1097/01.aog.0000228507.24471.1f |
| Popis: | OBJECTIVE: Maternal serum free beta-human chorionic gonadotropin (beta-hCG) and pregnancy-associated plasma protein-A (PAPP-A) have been used effectively in the screening of Down syndrome in the first trimester. In this study, we aim to measure the value of first-trimester maternal serum free beta-hCG and PAPP-A as predictors of homozygous alpha0-thalassemia-affected pregnancies. METHODS: Free beta-hCG and PAPP-A concentrations were measured in stored maternal serum samples obtained at 12 weeks of gestation from 22 women with fetuses affected by homozygous alpha0-thalassemia and from 436 controls matched for maternal age, ethnicity, and weight, as well as gestation at blood sampling. RESULTS: Maternal serum concentration of free beta-hCG was significantly increased in women with pregnancies affected by homozygous alpha0-thalassemia than in controls (P = .001). Concentrations of PAPP-A did not differ between the cases affected by homozygous alpha0-thalassemia and the controls (P = .652). CONCLUSION: Pregnancies affected by homozygous alpha0-thalassemia are associated with increased maternal serum free beta-hCG at 11-14 weeks of gestation. This serum analyte alone may not be clinically useful as a predictor of pregnancies affected by homozygous alpha0-thalassemia. However, the absence of ultrasound features of fetal anemia and hydropic changes, together with normal maternal serum free beta-hCG and PAPP-A in the first trimester, will be reassuring signs of normality for fetuses at risk of homozygous alpha0-thalassemia and, hence, enable women to avoid invasive tests in unaffected pregnancies. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|