Up-Regulation of Renin-Angiotensin System in Diabetes and Hypertension: Implications on the Development of Diabetic Nephropathy

Autor: Danielle Yuri Arita, Danielle Sanches Aragão, Rodolfo Mattar Rosa, Tatiana Sousa Cunha, Dulce Elena Casarini, Nadia de Sousa da Cunha Bertoncello, Fernanda Klein Marcondes, Fernanda Aparecida Ronchi
Rok vydání: 2012
Předmět:
Zdroj: Diabetic Nephropathy
DOI: 10.5772/36852
Popis: The growing worldwide epidemic of metabolic syndrome and other chronic degenerative diseases continues to expand, with a rapid decrease in the age at which they are being diagnosed (Guarnieri et al.; 2010; Hsueh & Wyne, 2011). Metabolic syndrome is a multifactorial disorder, strongly influenced by several lifestyle factors, with symptoms clustering on abnormalities that include obesity, hypertension, dyslipidemia, glucose intolerance and insulin resistance (Guarnieri et al.; 2010; Tanaka et al.; 2006). The syndrome is also referred to as “Diabesity” highlighting the incidence of diabetes mellitus (DM) in combination with obesity as a result of changes in human behavior (Astrup & Finer, 2000; Farag & Gaballa, 2011; Hu, 2011).
Databáze: OpenAIRE