Cholinergic and serotonergic modulations differentially affect large-scale functional networks in the mouse brain
| Autor: | Ines Blockx, Elisabeth Jonckers, Firat Kara, Georgios A. Keliris, Disha Shah, Marleen Verhoye, Anne-Marie Van Der Linden |
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| Rok vydání: | 2015 |
| Předmět: |
Male
functional networks 0301 basic medicine Serotonin medicine.medical_specialty Histology Neurology Scopolamine Thalamus serotonergic Muscarinic Antagonists Serotonergic Piperazines Mice 03 medical and health sciences 0302 clinical medicine Retrosplenial cortex Neural Pathways default-mode network medicine Animals Hypnotics and Sedatives Biology Cholinergic Default mode network Brain Mapping General Neuroscience functional connectivity Brain Human brain Medetomidine medicine.disease Magnetic Resonance Imaging Receptors Muscarinic Acetylcholine Mice Inbred C57BL 030104 developmental biology medicine.anatomical_structure Receptors Serotonin mouse brain Autism Human medicine Serotonin Antagonists Anatomy Psychology Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Brain structure & function Brain Structure and Function |
| ISSN: | 1863-2661 1863-2653 |
| DOI: | 10.1007/s00429-015-1087-7 |
| Popis: | Resting-state functional MRI (rsfMRI) is a widely implemented technique used to investigate large-scale topology in the human brain during health and disease. Studies in mice provide additional advantages, including the possibility to flexibly modulate the brain by pharmacological or genetic manipulations in combination with high-throughput functional connectivity (FC) investigations. Pharmacological modulations that target specific neurotransmitter systems, partly mimicking the effect of pathological events, could allow discriminating the effect of specific systems on functional network disruptions. The current study investigated the effect of cholinergic and serotonergic antagonists on large-scale brain networks in mice. The cholinergic system is involved in cognitive functions and is impaired in, e.g., Alzheimer's disease, while the serotonergic system is involved in emotional and introspective functions and is impaired in, e.g., Alzheimer's disease, depression and autism. Specific interest goes to the default-mode-network (DMN), which is studied extensively in humans and is affected in many neurological disorders. The results show that both cholinergic and serotonergic antagonists impaired the mouse DMN-like network similarly, except that cholinergic modulation additionally affected the retrosplenial cortex. This suggests that both neurotransmitter systems are involved in maintaining integrity of FC within the DMN-like network in mice. Cholinergic and serotonergic modulations also affected other functional networks, however, serotonergic modulation impaired the frontal and thalamus networks more extensively. In conclusion, this study demonstrates the utility of pharmacological rsfMRI in animal models to provide insights into the role of specific neurotransmitter systems on functional networks in neurological disorders. |
| Databáze: | OpenAIRE |
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